@article{RN22b,

title = {Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice},

author = {Gaudenzio, N. and Sibilano, R. and Starkl, P. and Tsai, M. and Galli, S. J. and Reber, L. L.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26068439},

doi = {10.3791/52753},

issn = {1940-087X (Electronic) 

1940-087X (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {J Vis Exp},

number = {99},

pages = {e52753},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN27b,

title = {Integration of interventional bronchoscopy in the management of lung cancer},

author = {Guibert, N. and Mazieres, J. and Marquette, C. H. and Rouviere, D. and Didier, A. and Hermant, C.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26324799},

doi = {10.1183/16000617.00010014},

issn = {1600-0617 (Electronic) 

0905-9180 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Eur Respir Rev},

volume = {24},

number = {137},

pages = {378-91},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN31b,

title = {[Immunotherapy in non-small cell lung cancer: inhibition of PD1/PDL1 pathway]},

author = {Guilleminault, L. and Carmier, D. and Heuze-Vourc'h, N. and Diot, P. and Pichon, E.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25687821},

doi = {10.1016/j.pneumo.2014.11.004},

issn = {0761-8417 (Print) 

0761-8417 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Rev Pneumol Clin},

volume = {71},

number = {1},

pages = {44-56},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN36b,

title = {A good night for a bad day},

author = {Guilleminault, L. and Sigmann, M. H. and Paganin, F.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25858908},

doi = {10.1136/thoraxjnl-2015-206955},

issn = {1468-3296 (Electronic) 

0040-6376 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Thorax},

volume = {70},

number = {6},

pages = {604, 607},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN44b,

title = {Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys},

author = {Marchand, S. and Bouchene, S. and de Monte, M. and Guilleminault, L. and Montharu, J. and Cabrera, M. and Gregoire, N. and Gobin, P. and Diot, P. and Couet, W. and Vecellio, L.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26040660},

doi = {10.1007/s11095-015-1716-0},

issn = {1573-904X (Electronic) 

0724-8741 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Pharm Res},

volume = {32},

number = {10},

pages = {3403-14},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN48b,

title = {Emergence of community-acquired Clostridium difficile infection: the experience of a French hospital and review of the literature},

author = {Ogielska, M. and Lanotte, P. and Le Brun, C. and Valentin, A. S. and Garot, D. and Tellier, A. C. and Halimi, J. M. and Colombat, P. and Guilleminault, L. and Lioger, B. and Vegas, H. and De Toffol, B. and Constans, T. and Bernard, L.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26092300},

doi = {10.1016/j.ijid.2015.06.007},

issn = {1878-3511 (Electronic) 

1201-9712 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Int J Infect Dis},

volume = {37},

pages = {36-41},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN50b,

title = {Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes},

author = {Pillard, F. and Lavit, M. and Cances, V. L. and Rami, J. and Houin, G. and Didier, A. and Riviere, D.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26704899},

doi = {10.1186/s12931-015-0315-2},

issn = {1465-993X (Electronic) 

1465-9921 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Respir Res},

volume = {16},

pages = {155},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN51b,

title = {The impact of allergic rhinitis on the management of asthma in a working population},

author = {Provost, D. and Iwatsubo, Y. and Riviere, S. and Mevel, M. and Didier, A. and Brochard, P. and Imbernon, E. and Raherison, C.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26553257},

doi = {10.1186/s12890-015-0136-6},

issn = {1471-2466 (Electronic) 

1471-2466 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {BMC Pulm Med},

volume = {15},

pages = {142},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN60b,

title = {A large and unusual lung abscess with positive culture to Slackia exigua},

author = {Roingeard, C. and Jaubert, J. and Guilleminault, L.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26432408},

doi = {10.1016/j.ijid.2015.09.015},

issn = {1878-3511 (Electronic) 

1201-9712 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Int J Infect Dis},

volume = {40},

pages = {37-8},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN62b,

title = {Efficiency of a phone coaching program on adherence to continuous positive airway pressure in sleep apnea hypopnea syndrome: a randomized trial},

author = {Sedkaoui, K. and Leseux, L. and Pontier, S. and Rossin, N. and Leophonte, P. and Fraysse, J. L. and Didier, A.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/26370444},

doi = {10.1186/s12890-015-0099-7},

issn = {1471-2466 (Electronic) 

1471-2466 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {BMC Pulm Med},

volume = {15},

pages = {102},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN1024,

title = {Heparan sulfate saccharides modify focal adhesions: implication in mucopolysaccharidosis neuropathophysiology},

author = {Bruyere, J. and Roy, E. and Ausseil, J. and Lemonnier, T. and Teyre, G. and Bohl, D. and Etienne-Manneville, S. and Lortat-Jacob, H. and Heard, J. M. and Vitry, S.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25268803},

doi = {10.1016/j.jmb.2014.09.012},

issn = {1089-8638 (Electronic) 

0022-2836 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {J Mol Biol},

volume = {427},

number = {4},

pages = {775-791},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN1021,

title = {Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model},

author = {Martins, C. and Hulkova, H. and Dridi, L. and Dormoy-Raclet, V. and Grigoryeva, L. and Choi, Y. and Langford-Smith, A. and Wilkinson, F. L. and Ohmi, K. and DiCristo, G. and Hamel, E. and Ausseil, J. and Cheillan, D. and Moreau, A. and Svobodova, E. and Hajkova, Z. and Tesarova, M. and Hansikova, H. and Bigger, B. W. and Hrebicek, M. and Pshezhetsky, A. V.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25567323},

doi = {10.1093/brain/awu355},

issn = {1460-2156 (Electronic) 

0006-8950 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {Brain},

volume = {138},

number = {Pt 2},

pages = {336-55},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN1023,

title = {Oxidative stress is independent of inflammation in the neurodegenerative Sanfilippo syndrome type B},

author = {Trudel, S. and Trecherel, E. and Gomila, C. and Peltier, M. and Aubignat, M. and Gubler, B. and Morliere, P. and Heard, J. M. and Ausseil, J.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/25332157},

doi = {10.1002/jnr.23497},

issn = {1097-4547 (Electronic) 

0360-4012 (Linking)},

year  = {2015},

date = {2015-01-01},

journal = {J Neurosci Res},

volume = {93},

number = {3},

pages = {424-32},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Persistence of Toxoplasma gondii in the central nervous system: a fine tuned balance between the parasite, the brain and the immune system},

author = {Blanchard, N. and Dunay, I. R. and Schluter, D.},

year  = {2015},

date = {2015-01-01},

journal = {Parasite Immunol},

abstract = {Upon infection of humans and animals with Toxoplasma gondii, the parasites persist as intraneuronal cysts that are controlled, but not eliminated by the immune system. In particular, intracerebral T cells are crucial in the control of T. gondii infection and are supported by essential functions from other leukocyte populations. Additionally, brain-resident cells including astrocytes, microglia and neurons contribute to the intracerebral immune response by the production of cytokines, chemokines and expression of immunoregulatory cell surface molecules, such as major histocompatibility (MHC) antigens. However, the in vivo behaviour of these individual cell populations, specifically their interaction during cerebral toxoplasmosis, remains to be elucidated. We discuss here what is known about the function of T cells, recruited myeloid cells and brain-resident cells, with particular emphasis on the potential cross-regulation of these cell populations, in governing cerebral toxoplasmosis. This article is protected by copyright. All rights reserved.},

note = {Blanchard, Nicolas 

Dunay, Ildiko Rita 

Schluter, Dirk 

Parasite Immunol. 2015 Jan 9. doi: 10.1111/pim.12173.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in pregnant women in Yaounde, Cameroon: emergence of highly resistant pfdhfr/pfdhps alleles},

author = {Chauvin, P. and Menard, S. and Iriart, X. and Nsango, S. E. and Tchioffo, M. T. and Abate, L. and Awono-Ambene, P. H. and Morlais, I. and Berry, A.},

year  = {2015},

date = {2015-01-01},

journal = {J Antimicrob Chemother},

volume = {70},

number = {9},

pages = {2566-71},

abstract = {OBJECTIVES: To determine, 6 years after the adoption of intermittent preventive treatment of pregnant women with sulfadoxine/pyrimethamine (IPTp-SP) in Cameroon, (i) the polymorphism and prevalence of Plasmodium falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) gene mutations associated with sulfadoxine/pyrimethamine resistance and (ii) the consequences of sulfadoxine/pyrimethamine use in the selection of pfdhfr/pfdhps alleles. METHODS: pfdhfr and pfdhps genes from P. falciparum isolates collected in Yaounde (Cameroon) from pregnant women with symptomatic malaria before taking IPTp-SP [SP- group (control) (n = 51)] or afterwards [SP+ group (n = 49)] were sequenced. RESULTS: The pfdhfr N51I, C59R, S108N triple mutant had a prevalence close to 100% (96/100) and no mutations at codons 50 and 164 were detected in either of the groups. The most frequent pfdhps mutation was A437G with a prevalence of 76.5% (39/51) in the SP- group, which was significantly higher in pregnant women who took sulfadoxine/pyrimethamine [95.9% (47/49)] (P = 0.012). Our study confirmed the presence of the pfdhps K540E mutation in Cameroon, but it remained rare. The prevalence of pfdhps A581G and A613S mutations had increased [5.9% (3/51) and 11.8% (6/51) in the control group, respectively] since the last studies in 2005. Surprisingly, the new pfdhps I431V mutation was detected, at a prevalence of 9.8% (5/51), and was found to be associated with other pfdhfr/pfdhps alleles to form an octuple N51I, C59R, S108N/I431V, S436A, A437G, A581G, A613S mutant. CONCLUSIONS: Significant changes were found in pfdhps polymorphism. In particular, we observed several parasites carrying eight mutations in pfdhfr/pfdhps genes, which are very susceptible to having a high level of resistance to sulfadoxine/pyrimethamine.},

note = {Chauvin, Pamela 

Menard, Sandie 

Iriart, Xavier 

Nsango, Sandrine E 

Tchioffo, Majoline T 

Abate, Luc 

Awono-Ambene, Parfait H 

Morlais, Isabelle 

Berry, Antoine 

England 

J Antimicrob Chemother. 2015 Sep;70(9):2566-71. doi: 10.1093/jac/dkv160. Epub 2015 Jun 16.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence},

author = {Joulia, R. and Gaudenzio, N. and Rodrigues, M. and Lopez, J. and Blanchard, N. and Valitutti, S. and Espinosa, E.},

year  = {2015},

date = {2015-01-01},

journal = {Nat Commun},

volume = {6},

pages = {6174},

abstract = {Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sustained exposure of effector enzymes, such as tryptase and chymase, at the cell-cell contact site. This previously unidentified mast cell effector mechanism, which we name the antibody-dependent degranulatory synapse (ADDS), is triggered by both IgE- and IgG-targeted cells. ADDSs take place within an area of cortical actin cytoskeleton clearance in the absence of microtubule organizing centre and Golgi apparatus repositioning towards the stimulating cell. Remarkably, IgG-mediated degranulatory synapses also occur upon contact with opsonized Toxoplasma gondii tachyzoites resulting in tryptase-dependent parasite death. Our results broaden current views of mast cell degranulation by revealing that human mast cells form degranulatory synapses with antibody-targeted cells and pathogens for dedicated secretion and defence.},

note = {Joulia, Regis 

Gaudenzio, Nicolas 

Rodrigues, Magda 

Lopez, Jodie 

Blanchard, Nicolas 

Valitutti, Salvatore 

Espinosa, Eric 

England 

Nat Commun. 2015 Jan 28;6:6174. doi: 10.1038/ncomms7174.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen},

author = {Lopez, J. and Bittame, A. and Massera, C. and Vasseur, V. and Effantin, G. and Valat, A. and Buaillon, C. and Allart, S. and Fox, B. A. and Rommereim, L. M. and Bzik, D. J. and Schoehn, G. and Weissenhorn, W. and Dubremetz, J. F. and Gagnon, J. and Mercier, C. and Cesbron-Delauw, M. F. and Blanchard, N.},

year  = {2015},

date = {2015-01-01},

journal = {Cell Rep},

abstract = {Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their parasitophorous vacuole (PV), resulting in host cell subversion and potential presentation by MHC class I molecules for CD8 T cell recognition. The host-parasite interface comprises the PV limiting membrane and a highly curved, membranous intravacuolar network (IVN) of uncertain function. Here, using a cell-free minimal system, we dissect how membrane tubules are shaped by the parasite effectors GRA2 and GRA6. We show that membrane association regulates access of the GRA6 protective antigen to the MHC I pathway in infected cells. Although insertion of GRA6 in the PV membrane is key for immunogenicity, association of GRA6 with the IVN limits presentation and curtails GRA6-specific CD8 responses in mice. Thus, membrane deformations of the PV regulate access of antigens to the MHC class I pathway, and the IVN may play a role in immune modulation.},

note = {Lopez, Jodie 

Bittame, Amina 

Massera, Celine 

Vasseur, Virginie 

Effantin, Gregory 

Valat, Anne 

Buaillon, Celia 

Allart, Sophie 

Fox, Barbara A 

Rommereim, Leah M 

Bzik, David J 

Schoehn, Guy 

Weissenhorn, Winfried 

Dubremetz, Jean-Francois 

Gagnon, Jean 

Mercier, Corinne 

Cesbron-Delauw, Marie-France 

Blanchard, Nicolas 

Cell Rep. 2015 Nov 23. pii: S2211-1247(15)01288-7. doi: 10.1016/j.celrep.2015.11.001.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure},

author = {Menard, S. and Ben Haddou, T. and Ramadani, A. P. and Ariey, F. and Iriart, X. and Beghain, J. and Bouchier, C. and Witkowski, B. and Berry, A. and Mercereau-Puijalon, O. and Benoit-Vical, F.},

year  = {2015},

date = {2015-01-01},

journal = {Emerg Infect Dis},

volume = {21},

number = {10},

pages = {1733-41},

abstract = {Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia threatens global malaria control strategies. Whether delayed parasite clearance, which exposes larger parasite numbers to artemisinins for longer times, selects higher-grade resistance remains unexplored. We investigated whether long-lasting artemisinin pressure selects a novel multidrug-tolerance profile. Although 50% inhibitory concentrations for 10 antimalarial drugs tested were unchanged, drug-tolerant parasites showed higher recrudescence rates for endoperoxides, quinolones, and an antifolate, including partner drugs of recommended combination therapies, but remained susceptible to atovaquone. Moreover, the age range of intraerythrocytic stages able to resist artemisinin was extended to older ring forms and trophozoites. Multidrug tolerance results from drug-induced quiescence, which enables parasites to survive exposure to unrelated antimalarial drugs that inhibit a variety of metabolic pathways. This novel resistance pattern should be urgently monitored in the field because this pattern is not detected by current assays and represents a major threat to antimalarial drug policy.},

note = {Menard, Sandie 

Ben Haddou, Tanila 

Ramadani, Arba Pramundita 

Ariey, Frederic 

Iriart, Xavier 

Beghain, Johann 

Bouchier, Christiane 

Witkowski, Benoit 

Berry, Antoine 

Mercereau-Puijalon, Odile 

Benoit-Vical, Francoise 

Emerg Infect Dis. 2015 Oct;21(10):1733-41. doi: 10.3201/eid2110.150682.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Persistence of Toxoplasma gondii in the central nervous system: a fine tuned balance between the parasite, the brain and the immune system},

author = {Blanchard, N. and Dunay, I. R. and Schluter, D.},

year  = {2015},

date = {2015-01-01},

journal = {Parasite Immunol},

abstract = {Upon infection of humans and animals with Toxoplasma gondii, the parasites persist as intraneuronal cysts that are controlled, but not eliminated by the immune system. In particular, intracerebral T cells are crucial in the control of T. gondii infection and are supported by essential functions from other leukocyte populations. Additionally, brain-resident cells including astrocytes, microglia and neurons contribute to the intracerebral immune response by the production of cytokines, chemokines and expression of immunoregulatory cell surface molecules, such as major histocompatibility (MHC) antigens. However, the in vivo behaviour of these individual cell populations, specifically their interaction during cerebral toxoplasmosis, remains to be elucidated. We discuss here what is known about the function of T cells, recruited myeloid cells and brain-resident cells, with particular emphasis on the potential cross-regulation of these cell populations, in governing cerebral toxoplasmosis. This article is protected by copyright. All rights reserved.},

note = {Jan 9. doi: 10.1111/pim.12173.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in pregnant women in Yaounde, Cameroon: emergence of highly resistant pfdhfr/pfdhps alleles},

author = {Chauvin, P. and Menard, S. and Iriart, X. and Nsango, S. E. and Tchioffo, M. T. and Abate, L. and Awono-Ambene, P. H. and Morlais, I. and Berry, A.},

year  = {2015},

date = {2015-01-01},

journal = {J Antimicrob Chemother},

volume = {70},

number = {9},

pages = {2566-71},

abstract = {OBJECTIVES: To determine, 6 years after the adoption of intermittent preventive treatment of pregnant women with sulfadoxine/pyrimethamine (IPTp-SP) in Cameroon, (i) the polymorphism and prevalence of Plasmodium falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) gene mutations associated with sulfadoxine/pyrimethamine resistance and (ii) the consequences of sulfadoxine/pyrimethamine use in the selection of pfdhfr/pfdhps alleles. METHODS: pfdhfr and pfdhps genes from P. falciparum isolates collected in Yaounde (Cameroon) from pregnant women with symptomatic malaria before taking IPTp-SP [SP- group (control) (n = 51)] or afterwards [SP+ group (n = 49)] were sequenced. RESULTS: The pfdhfr N51I, C59R, S108N triple mutant had a prevalence close to 100% (96/100) and no mutations at codons 50 and 164 were detected in either of the groups. The most frequent pfdhps mutation was A437G with a prevalence of 76.5% (39/51) in the SP- group, which was significantly higher in pregnant women who took sulfadoxine/pyrimethamine [95.9% (47/49)] (P = 0.012). Our study confirmed the presence of the pfdhps K540E mutation in Cameroon, but it remained rare. The prevalence of pfdhps A581G and A613S mutations had increased [5.9% (3/51) and 11.8% (6/51) in the control group, respectively] since the last studies in 2005. Surprisingly, the new pfdhps I431V mutation was detected, at a prevalence of 9.8% (5/51), and was found to be associated with other pfdhfr/pfdhps alleles to form an octuple N51I, C59R, S108N/I431V, S436A, A437G, A581G, A613S mutant. CONCLUSIONS: Significant changes were found in pfdhps polymorphism. In particular, we observed several parasites carrying eight mutations in pfdhfr/pfdhps genes, which are very susceptible to having a high level of resistance to sulfadoxine/pyrimethamine.},

note = {Sep;70(9):2566-71. doi: 10.1093/jac/dkv160. Epub 2015 Jun 16.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}