On Thursday, November 18, 2021, the Fondation Vaincre Alzheimer organized at Infinity lab, an open lab day to meet with donors and to present the research project of Benjamin Schmitt, a PhD thesis student funded by the Foundation. The general goal of his project is to combat the inflammation of the brain that is observed during the course of the disease and to improve the repair of neuronal DNA to improve memory.
Dr. Elsa Suberbielle, CNRS researcher in the team of Dr. Daniel Dunia and Dr. Cécile Malnou, discovered that in Alzheimer’s disease, DNA breaks abnormally accumulate in the neurons. This accumulation is due to a defect in DNA repair proteins. This accumulation could be linked to the inflammatory reaction in the brain (called neuroinflammation). Hence, these breaks may play a key role in cognitive decline in AD and other neuroinflammatory and neurodegenerative diseases.
Dr. Elsa Suberbielle, as an expert neuroscience and behavior, is one of 16 awardees currently funded by the Fondation Vaincre Alzheimer. Since 2013, Dr. Suberbielle’s research has focused on understanding the pathological mechanisms underlying cognitive decline in AD in order to find new cures to combat it.