@article{C2022,

title = {Identification of bacterial lipopeptides as key players in IBS},

author = {Petitfils C, Maurel S, Payros G, Hueber A, Agaiz B, Gazzo G, Marrocco R, Auvray F, Langevin G, Motta JP, Floch P, Tremblay-Franco M, Galano JM, Guy A, Durand T, Lachambre S, Durbec A, Hussein H, Decraecker L, Bertrand-Michel J, Saoudi A, Oswald E, Poisbeau P, Dietrich G, Melchior C, Boeckxstaens G, Serino M, Le Faouder P, Cenac N.},

url = {https://pubmed.ncbi.nlm.nih.gov/36241390/},

doi = {10.1136/gutjnl-2022-328084},

year  = {2022},

date = {2022-10-14},

journal = {Gut},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN2021,

title = {Ca(v)1.4 calcium channels control cytokine production by human peripheral T(H)17 cells and psoriatic skin-infiltrating T cells},

author = {Mars, M. and Neant, I. and Leclerc, C. and Bosch, S. and Rouviere, C. and Moreau, M. and Lachambre, S. and Paul, C. and Tauber, M. and Gravier, E. and Douzal, C. and Duplan, H. and Babin, M. and Brocario, A. and Thouvenin, M. D. and Guery, J. C. and Redoules, D. and Lestienne, F. and Pelletier, L. and Savignac, M.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/34653514},

doi = {10.1016/j.jaci.2021.09.030},

issn = {1097-6825 (Electronic) 0091-6749 (Linking)},

year  = {2022},

date = {2022-01-01},

journal = {J Allergy Clin Immunol},

volume = {149},

number = {4},

pages = {1348-1357},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Briand-Mesange2020,

title = {Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch},

author = {Briand-M{é}sange, Fabienne and Pons, V{é}ronique and Allart, Sophie and Masquelier, Julien and Chicanne, Ga{ë}tan and Beton, Nicolas and Payrastre, Bernard and Muccioli, Giulio G. and Ausseil, J{é}r{ô}me and Davignon, Jean Luc and Salles, Jean Pierre and Chap, Hugues},

doi = {10.1074/jbc.RA120.015278},

issn = {1083351X},

year  = {2020},

date = {2020-11-01},

journal = {Journal of Biological Chemistry},

volume = {295},

number = {46},

pages = {15767--15781},

publisher = {American Society for Biochemistry and Molecular Biology Inc.},

abstract = {Endocannabinoid signaling plays a regulatory role in various (neuro)biological functions. 2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid, and although its canonical biosynthetic pathway involving phosphoinositide-specific phospholipase C and diacylglycerol lipase a is known, alternative pathways remain unsettled. Here, we characterize a non-canonical pathway implicating glycerophosphodiesterase 3 (GDE3, from GDPD2 gene). Human GDE3 expressed in HEK293T cell membranes catalyzed the conversion of lysophosphatidylinositol (LPI) into monoacylglycerol and inositol-1-phosphate. The enzyme was equally active against 1-acyl and 2-acyl LPI. When using 2-acyl LPI, where arachidonic acid is the predominant fatty acid, LC-MS analysis identified 2-AG as the main product of LPI hydrolysis by GDE3. Furthermore, inositol-1-phosphate release into the medium occurred upon addition of LPI to intact cells, suggesting that GDE3 is actually an ecto-lysophospholipase C. In cells expressing G-protein–coupled receptor GPR55, GDE3 abolished 1-acyl LPI–induced signaling. In contrast, upon simultaneous expression of GDE3 and cannabinoid receptor CB2, 2-acyl LPI evoked the same signal as that induced by 2-AG. These data strongly suggest that, in addition to degrading the GPR55 LPI ligand, GDE3 can act as a switch between GPR55 and CB2 signaling. Coincident with a major expression of both GDE3 and CB2 in the spleen, spleens from transgenic mice lacking GDE3 displayed doubling of LPI content compared with WT mice. Decreased production of 2-AG in whole spleen was also observed, supporting the in vivo relevance of our findings. These data thus open a new research avenue in the field of endocannabinoid generation and reinforce the view of GPR55 and LPI being genuine actors of the endocannabinoid system.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Reynier2019,

title = {The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity.},

author = {Reynier, Marie and Allart, Sophie and Goudounèche, Dominique and Moga, Alain and Serre, Guy and Simon, Michel and Leprince, Corinne},

doi = {10.1016/j.jid.2018.12.021},

issn = {1523-1747 (Electronic)},

year  = {2019},

date = {2019-07-01},

journal = {The Journal of investigative dermatology},

volume = {139},

number = {7},

pages = {1430--1438},

abstract = {Myosin Vb (Myo5b) is an unconventional myosin involved in the actin-dependent transport and tethering of intracellular organelles. In the epidermis, granular keratinocytes accumulate cytoplasmic lamellar bodies (LBs), secretory vesicles released at the junction with the stratum corneum that participate actively in the maintenance of the epidermal barrier. We have previously demonstrated that LB biogenesis is controlled by the Rab11a guanosine triphosphate hydrolase, known for its ability to recruit the Myo5b motor. In order to better characterize the molecular pathway that controls LB trafficking, we analyzed the role of F-actin and Myo5b in the epidermis. We demonstrated that LB distribution in granular keratinocytes was dependent on a dynamic F-actin cytoskeleton. Myo5b was shown to be highly expressed in granular keratinocytes and associated with corneodesmosin-loaded LB. In reconstructed human epidermis, Myo5b silencing led to epidermal barrier defects associated with structural alterations of the stratum corneum and a reduced pool of LB showing signs of disordered maturation. Myo5b depletion also disturbed the expression and distribution of both LB cargoes and junctional components, such as claudin-1, which demonstrates its action on both LB trafficking and junctional complex composition. Together, our data reveal the essential role of Myo5b in maintaining the epidermal barrier integrity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN24,

title = {The beta and alpha2delta auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation},

author = {Rosa, N. and Triffaux, E. and Robert, V. and Mars, M. and Klein, M. and Bouchaud, G. and Canivet, A. and Magnan, A. and Guery, J. C. and Pelletier, L. and Savignac, M.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/29129580

https://www.sciencedirect.com/science/article/pii/S0091674917317402},

doi = {10.1016/j.jaci.2017.09.045},

issn = {1097-6825 (Electronic) 0091-6749 (Linking)},

year  = {2018},

date = {2018-09-01},

journal = {J Allergy Clin Immunol},

volume = {142},

number = {3},

pages = {892-903},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN25b,

title = {TLR7 escapes X chromosome inactivation in immune cells},

author = {Souyris, M. and Cenac, C. and Azar, P. and Daviaud, D. and Canivet, A. and Grunenwald, S. and Pienkowski, C. and Chaumeil, J. and Mejia, J. E. and Guery, J. C.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/29374079},

doi = {10.1126/sciimmunol.aap8855},

issn = {2470-9468 (Electronic) 2470-9468 (Linking)},

year  = {2018},

date = {2018-01-26},

journal = {Sci Immunol},

volume = {3},

number = {19},

note = {In the top 5% of all research outputs scored by Altmetric. http://www.altmetric.com/details/32261033},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{rey-barroso_switching_2018,

title = {Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions},

author = { Javier Rey-Barroso and Daniel S. Calovi and Maud Combe and Yolla German and Mathieu Moreau and Astrid Canivet and Xiaobo Wang and Clément Sire and Guy Theraulaz and Loïc Dupré},

doi = {10.1038/s41598-018-24222-4},

issn = {2045-2322},

year  = {2018},

date = {2018-01-01},

journal = {Scientific Reports},

volume = {8},

number = {1},

pages = {5800},

abstract = {Lymphocytes alternate between phases of individual migration across tissues and phases of clustering during activation and function. The range of lymphocyte motility behaviors and the identity of the factors that govern them remain elusive. To explore this point, we here collected unprecedented statistics pertaining to cell displacements, cell:matrix and cell:cell interactions using a model B cell line as well as primary human B lymphocytes. At low cell density, individual B lymphocytes displayed a high heterogeneity in their speed and diffusivity. Beyond this intrinsic variability, B lymphocytes adapted their motility to the composition of extra-cellular matrix, adopting slow persistent walks over collagen IV and quick Brownian walks over fibronectin. At high cell density, collagen IV favored the self-assembly of B lymphocytes into clusters endowed with collective coordination, while fibronectin stimulated individual motility. We show that this behavioral plasticity is controlled by acto-myosin dependent adhesive and Arp2/3-dependent protrusive actin pools, respectively. Our study reveals the adaptive nature of B lymphocyte motility and group dynamics, which are shaped by an interplay between and cell:matrix and cell:cell interactions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN3b,

title = {The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse},

author = {Houmadi, R. and Guipouy, D. and Rey-Barroso, J. and Vasconcelos, Z. and Cornet, J. and Manghi, M. and Destainville, N. and Valitutti, S. and Allart, S. and Dupre, L.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/29386139},

doi = {10.1016/j.celrep.2017.12.088},

issn = {2211-1247 (Electronic)},

year  = {2018},

date = {2018-01-01},

journal = {Cell Rep},

volume = {22},

number = {4},

pages = {979-991},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN881,

title = {Vectorial Release of Hepatitis E Virus in Polarized Human Hepatocytes},

author = {Capelli, N. and Marion, O. and Dubois, M. and Allart, S. and Bertrand-Michel, J. and Lhomme, S. and Abravanel, F. and Izopet, J. and Chapuy-Regaud, S.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/30463960},

doi = {10.1128/JVI.01207-18},

issn = {1098-5514 (Electronic) 0022-538X (Linking)},

year  = {2018},

date = {2018-01-01},

journal = {J Virol},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN9b,

title = {CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice},

author = {Bernard-Valnet, R. and Yshii, L. and Queriault, C. and Nguyen, X. H. and Arthaud, S. and Rodrigues, M. and Canivet, A. and Morel, A. L. and Matthys, A. and Bauer, J. and Pignolet, B. and Dauvilliers, Y. and Peyron, C. and Liblau, R. S.},

url = {http://www.ncbi.nlm.nih.gov/pubmed/27621438},

doi = {10.1073/pnas.1603325113},

issn = {1091-6490 (Electronic) 0027-8424 (Linking)},

year  = {2016},

date = {2016-01-01},

journal = {Proc Natl Acad Sci U S A},

volume = {113},

number = {39},

pages = {10956-61},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen},

author = {Lopez, J. and Bittame, A. and Massera, C. and Vasseur, V. and Effantin, G. and Valat, A. and Buaillon, C. and Allart, S. and Fox, B. A. and Rommereim, L. M. and Bzik, D. J. and Schoehn, G. and Weissenhorn, W. and Dubremetz, J. F. and Gagnon, J. and Mercier, C. and Cesbron-Delauw, M. F. and Blanchard, N.},

year  = {2015},

date = {2015-01-01},

journal = {Cell Rep},

abstract = {Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their parasitophorous vacuole (PV), resulting in host cell subversion and potential presentation by MHC class I molecules for CD8 T cell recognition. The host-parasite interface comprises the PV limiting membrane and a highly curved, membranous intravacuolar network (IVN) of uncertain function. Here, using a cell-free minimal system, we dissect how membrane tubules are shaped by the parasite effectors GRA2 and GRA6. We show that membrane association regulates access of the GRA6 protective antigen to the MHC I pathway in infected cells. Although insertion of GRA6 in the PV membrane is key for immunogenicity, association of GRA6 with the IVN limits presentation and curtails GRA6-specific CD8 responses in mice. Thus, membrane deformations of the PV regulate access of antigens to the MHC class I pathway, and the IVN may play a role in immune modulation.},

note = {Nov 23. pii: S2211-1247(15)01288-7. doi: 10.1016/j.celrep.2015.11.001.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}