Sex differences in immunity: mechanisms and pathophysiology

Coordinator : J.C. Guéry

Scientific objectives


The nature and strength of the immune response differ between women and men, resulting in sex-based differences in the prevalence, manifestations and outcome of autoimmune and infectious diseases. While women are able to mount a more vigorous immune response to infections, they also suffer more from autoimmune diseases and inflammation-induced tissue damages.
Growing data indicate that common biological pathways leading to inflammation and immune activation are involved in the pathophysiology of autoimmune and infectious diseases, and that these pathways are regulated by sex-linked factors, including sex hormones and sex-chromosome loci.
Our team is interested in understanding the mechanisms by which sex-specific factors regulate the immune responses. Our current research objectives focus on three main areas:

 

Intro

Our projects


AXIS 1: Protective effect of estrogens on CNS autoimmunity

Multiple sclerosis (MS) is a T cell-mediated autoimmune disease characterized by the infiltration of inflammatory leukocytes into the central nervous system resulting in myelin damages.

Clinical remissions in MS patients are frequent during pregnancy suggesting that hormones such as 17ß-estradiol (E2) could be protective. Indeed, beneficial effects of estrogen therapy have mainly been documented in experimental autoimmune encephalomyelitis (EAE) in mice and in MS patients.
Using genetic mouse models, we discovered that the anti-inflammatory action of E2 in EAE relies on ERa-, but not ERß-expression in T lymphocytes.
Using new genetic mouse models, the group is investigating the underlying mechanisms responsible for the anti-inflammatory effect of estrogens in EAE. This may lead to the development of innovative therapies in an effort to mimic the protective effect of pregnancy in women with MS.

AXE 2: Role of sex-linked factors in the regulation of innate immunity

In recent studies, the laboratory provided evidence that estrogen-mediated activation of ER signaling is a key regulator of dendritic cell biology, which may account for the sex-based differences in autoimmune and infectious diseases.

Fig2

In particular, we discovered that the TLR-dependent type I IFN response of plasmacytoid dendritic cells is positively regulated by estrogens both in human and mouse.

Using genetic and cellular approaches, the group is investigating the underlying mechanisms by which sex hormones and X-linked factors could contribute to regulate innate and adaptive immunity in the context of autoimmune and infectious diseases.

AXIS 3: Understanding sex bias in infectious and allergic respiratory diseases

Sexual dimorphism is observed in the susceptibility to asthma, which is more frequent and more severe in women than in men. Likewise, women are more prone than men to develop a severe form of influenza virus infection.
Fig3

Fig3

In vivo models and genetic approaches using tissue-specific inhibition of candidate signaling pathways are being applied to dissect the cellular and molecular mechanisms involved.
In this context, the group recently established that androgen signaling is a potent negative regulator of group 2 innate lymphoid cells thereby attenuating type 2 lung inflammation in vivo. These results indicate that targeting androgen signaling or their downstream pathways may represent a new avenue for the treatment of allergic disorders.

Fig4

Fig4

In a second line of expertise, the team is also investigating the role of Cav1 calcium channels in Th2 cell biology and their implication in asthma. The group contributed to demonstrate the key role of some Cav1 channel isotypes in the regulation Th2 cell effector functions in mouse and human. Insights from the lab’s research may lead to the development of small molecule therapeutics for inflammatory diseases through the selective targeting of Cav1 channel family members.

Other informations


Publications

2024

Huret, C.; Ferraye, L.; David, A.; Mohamed, M.; Valentin, N.; Charlotte, F.; Savignac, M.; Goodhardt, M.; Guery, J. C.; Rougeulle, C.; Morey, C.

Altered X-chromosome inactivation predisposes to autoimmunity Journal Article

In: Sci Adv, vol. 10, no. 18, pp. eadn6537, 2024, ISSN: 2375-2548 (Electronic) 2375-2548 (Linking).

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Chi, L.; Liu, C.; Gribonika, I.; Gschwend, J.; Corral, D.; Han, S. J.; Lim, A. I.; Rivera, C. A.; Link, V. M.; Wells, A. C.; Bouladoux, N.; Collins, N.; Lima-Junior, D. S.; Enamorado, M.; Rehermann, B.; Laffont, S.; Guery, J. C.; Tussiwand, R.; Schneider, C.; Belkaid, Y.

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis Journal Article

In: Science, vol. 384, no. 6692, pp. eadk6200, 2024, ISSN: 1095-9203 (Electronic) 0036-8075 (Linking).

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2023

Youness, A.; Cenac, C.; Faz-Lopez, B.; Grunenwald, S.; Barrat, F. J.; Chaumeil, J.; Mejia, J. E.; Guery, J. C.

TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells Journal Article

In: Biol Sex Differ, vol. 14, no. 1, pp. 60, 2023, ISSN: 2042-6410 (Electronic) 2042-6410 (Linking).

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Renaudineau, Y.; Muller, S.; Hedrich, C. M.; Chauveau, D.; Belliere, J.; De Almeida, S.; Damoiseaux, J.; Scherlinger, M.; Guery, J. C.; Sailler, L.; Bost, C.

Immunological and translational key challenges in systemic lupus erythematosus: A symposium update Journal Article

In: J Transl Autoimmun, vol. 6, pp. 100199, 2023, ISSN: 2589-9090 (Electronic) 2589-9090 (Linking).

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Miquel, C. H.; Faz-Lopez, B.; Guery, J. C.

Influence of X chromosome in sex-biased autoimmune diseases Journal Article

In: J Autoimmun, vol. 137, pp. 102992, 2023, ISSN: 1095-9157 (Electronic) 0896-8411 (Linking).

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Miquel, C. H.; Abbas, F.; Cenac, C.; Foret-Lucas, C.; Guo, C.; Ducatez, M.; Joly, E.; Hou, B.; Guery, J. C.

B cell-intrinsic TLR7 signaling is required for neutralizing antibody responses to SARS-CoV-2 and pathogen-like COVID-19 vaccines Journal Article

In: Eur J Immunol, pp. e2350437, 2023, ISSN: 1521-4141 (Electronic) 0014-2980 (Linking).

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Giang, N.; Villeneuve, T.; Maire, K.; Mejia, J. E.; Guery, J. C.; Pelletier, L.; Savignac, M.

PKCalpha interacts with Ca(v) 1.3 calcium channels to promote the Ca(v) 1.2/Ca(v) 1.3 duo tuning Th2 functions Journal Article

In: Allergy, vol. 78, no. 3, pp. 879-882, 2023, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Anesi, N.; Miquel, C. H.; Laffont, S.; Guery, J. C.

The Influence of Sex Hormones and X Chromosome in Immune Responses Journal Article

In: Curr Top Microbiol Immunol, vol. 441, pp. 21-59, 2023, ISSN: 0070-217X (Print) 0070-217X (Linking).

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2022

Cenac, C.; Ducatez, M. F.; Guery, J. C.

Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells Journal Article

In: Eur J Immunol, vol. 52, no. 1, pp. 54-61, 2022, ISSN: 1521-4141 (Electronic) 0014-2980 (Linking).

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Congy-Jolivet, N.; Cenac, C.; Dellacasagrande, J.; Puissant-Lubrano, B.; Apoil, P. A.; Guedj, K.; Abbas, F.; Laffont, S.; Sourdet, S.; Guyonnet, S.; Nourhashemi, F.; Guery, J. C.; Blancher, A.

Monocytes are the main source of STING-mediated IFN-alpha production Journal Article

In: EBioMedicine, vol. 80, pp. 104047, 2022, ISSN: 2352-3964 (Electronic) 2352-3964 (Linking).

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Abbas, F.; Cenac, C.; Youness, A.; Azar, P.; Delobel, P.; Guery, J. C.

HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells Journal Article

In: Life Sci Alliance, vol. 5, no. 10, 2022, ISSN: 2575-1077 (Electronic) 2575-1077 (Linking).

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Giang, N.; Mars, M.; Moreau, M.; Mejia, J. E.; Bouchaud, G.; Magnan, A.; Michelet, M.; Ronsin, B.; Murphy, G. G.; Striessnig, J.; Guery, J. C.; Pelletier, L.; Savignac, M.

Separation of the Cav1.2-Cav1.3 calcium channel duo prevents type 2 allergic airway inflammation Journal Article

In: Allergy, vol. 77, no. 2, pp. 525-539, 2022, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Giang, N.; Villeneuve, T.; Maire, K.; Mejia, J. E.; Guery, J. C.; Pelletier, L.; Savignac, M.

PKCalpha interacts with Ca(v) 1.3 calcium channels to promote the Ca(v) 1.2/Ca(v) 1.3 duo tuning Th2 functions Journal Article

In: Allergy, 2022, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Blanquart, E.; Mandonnet, A.; Mars, M.; Cenac, C.; Anesi, N.; Mercier, P.; Audouard, C.; Roga, S.; Serrano de Almeida, G.; Bevan, C. L.; Girard, J. P.; Pelletier, L.; Laffont, S.; Guery, J. C.

Targeting androgen signaling in ILC2s protects from IL-33-driven lung inflammation, independently of KLRG1 Journal Article

In: J Allergy Clin Immunol, vol. 149, no. 1, pp. 237-251 e12, 2022, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Mars, M.; Neant, I.; Leclerc, C.; Bosch, S.; Rouviere, C.; Moreau, M.; Lachambre, S.; Paul, C.; Tauber, M.; Gravier, E.; Douzal, C.; Duplan, H.; Babin, M.; Brocario, A.; Thouvenin, M. D.; Guery, J. C.; Redoules, D.; Lestienne, F.; Pelletier, L.; Savignac, M.

Ca(v)1.4 calcium channels control cytokine production by human peripheral T(H)17 cells and psoriatic skin-infiltrating T cells Journal Article

In: J Allergy Clin Immunol, vol. 149, no. 4, pp. 1348-1357, 2022, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Bost, C.; Arleevskaya, M. I.; Brooks, W. H.; Plaza, S.; Guery, J. C.; Renaudineau, Y.

Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis Journal Article

In: Clin Immunol, vol. 236, pp. 108937, 2022, ISSN: 1521-7035 (Electronic) 1521-6616 (Linking).

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Corral, D.; Charton, A.; Krauss, M. Z.; Blanquart, E.; Levillain, F.; Lefrancais, E.; Sneperger, T.; Vahlas, Z.; Girard, J. P.; Eberl, G.; Poquet, Y.; Guery, J. C.; Arguello, R. J.; Belkaid, Y.; Mayer-Barber, K. D.; Hepworth, M. R.; Neyrolles, O.; Hudrisier, D.

ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection Journal Article

In: Cell Rep, vol. 39, no. 3, pp. 110715, 2022, ISSN: 2211-1247 (Electronic).

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2021

Youness, A.; Miquel, C. H.; Guéry, J. C.

Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases Journal Article

In: Int J Mol Sci, vol. 22, no. 3, 2021, ISSN: 1422-0067.

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Blanquart, E.; Mandonnet, A.; Mars, M.; Cenac, C.; Anesi, N.; Mercier, P.; Audouard, C.; Roga, S.; Serrano de Almeida, G.; Bevan, C. L.; Girard, J. P.; Pelletier, L.; Laffont, S.; Guery, J. C.

Targeting androgen signaling in ILC2s protects from IL-33-driven lung inflammation, independently of KLRG1 Journal Article

In: J Allergy Clin Immunol, 2021, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

Links | BibTeX

Cenac, C.; Ducatez, M.; Guery, J. C.

Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells Journal Article

In: Eur J Immunol, 2021, ISSN: 1521-4141 (Electronic) 0014-2980 (Linking).

Links | BibTeX

Blanquart, E.; Laffont, S.; Guery, J. C.

Sex hormone regulation of innate lymphoid cells Journal Article

In: Biomed J, vol. 44, no. 2, pp. 144-156, 2021, ISSN: 2320-2890 (Electronic) 2319-4170 (Linking).

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2020

Pelletier, L.; Guéry, J. C.

[Asthma and allergy: what about the differences between men and women?] Journal Article

In: Rev Prat, vol. 70, no. 2, pp. 195-199, 2020, ISSN: 0035-2640.

BibTeX

Azar, P.; Mejía, J. E.; Cenac, C.; Shaiykova, A.; Youness, A.; Laffont, S.; Essat, A.; Izopet, J.; Passaes, C.; Müller-Trutwin, M.; Delobel, P.; Meyer, L.; Guéry, J. C.

TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women Journal Article

In: JCI Insight, vol. 5, no. 12, 2020, ISSN: 2379-3708.

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2019

Guery, Jean-Charles

Why is systemic lupus erythematosus more common in women? Journal Article

In: Joint Bone Spine, vol. 86, no. 3, pp. 297-299, 2019, (invited editorial).

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Souyris, Melanie; Mejia, Jose E; Chaumeil, Julie; Guery, Jean-Charles

Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation. Journal Article

In: Semin Immunopathol, vol. 41, no. 2, pp. 153-164, 2019, ISSN: 1863-2300 (Electronic); 1863-2297 (Linking), (review).

Abstract | Links | BibTeX

Garnier, A.; Laffont, S.; Garnier, L.; Kaba, E.; Deutsch, U.; Engelhardt, B.; Guery, J. C.

CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation Journal Article

In: Eur J Immunol, 2019, ISSN: 0014-2980.

Abstract | Links | BibTeX

Laffont, S.; Guery, J. C.

Deconstructing the sex bias in allergy and autoimmunity: From sex hormones and beyond Journal Article

In: Adv Immunol, vol. 142, pp. 35-64, 2019, ISSN: 0065-2776, (review).

Abstract | Links | BibTeX

Domingo, Cristina; Fraissinet, Juliane; Ansah, Patrick O.; Kelly, Corey; Bhat, Niranjan; Sow, Samba O.; Mejía, José E.

Long-term immunity against yellow fever in children vaccinated during infancy: a longitudinal cohort study Journal Article

In: Lancet Infect Dis, 2019, ISSN: 1473-3099.

Abstract | Links | BibTeX

2018

Garnier, Laure; Laffont, Sophie; Lelu, Karine; Yogev, Nir; Waisman, Ari; Guery, Jean-Charles

Estrogen Signaling in Bystander Foxp3(neg) CD4(+) T Cells Suppresses Cognate Th17 Differentiation in Trans and Protects from Central Nervous System Autoimmunity. Journal Article

In: J Immunol, vol. 201, no. 11, pp. 3218–3228, 2018, ISSN: 1550-6606 (Electronic); 0022-1767 (Linking).

Abstract | Links | BibTeX

Rosa, N.; Triffaux, E.; Robert, V.; Mars, M.; Klein, M.; Bouchaud, G.; Canivet, A.; Magnan, A.; Guery, J. C.; Pelletier, L.; Savignac, M.

The beta and alpha2delta auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation Journal Article

In: J Allergy Clin Immunol, vol. 142, no. 3, pp. 892-903, 2018, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Pelletier, Lucette; Savignac, Magali

Involvement of ion channels in allergy Journal Article

In: Current Opinion in Immunology, vol. 52, pp. 60 - 67, 2018, ISSN: 0952-7915, (review).

Abstract | Links | BibTeX

Souyris, M.; Cenac, C.; Azar, P.; Daviaud, D.; Canivet, A.; Grunenwald, S.; Pienkowski, C.; Chaumeil, J.; Mejia, J. E.; Guery, J. C.

TLR7 escapes X chromosome inactivation in immune cells Journal Article

In: Sci Immunol, vol. 3, no. 19, 2018, ISSN: 2470-9468 (Electronic) 2470-9468 (Linking), (In the top 5% of all research outputs scored by Altmetric. http://www.altmetric.com/details/32261033).

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Blanquart, Eve; Laffont, Sophie; Guery, Jean-Charles

Effets protecteurs de la puberte chez les garcons dans les maladies allergiques : les androgenes, un regulateur negatif des cellules lymphoides innees de groupe 2 Journal Article

In: Rev Fr Allergol, vol. 5991, no. 4, pp. 297-357, 2018, ISSN: 1877-0320, (review).

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Laffont, Sophie; Blanquart, Eve; Guery, Jean-Charles

Sex-bias in allergic asthma: androgens and group 2 innate lymphoid cells Journal Article

In: Med Sci (Paris), vol. 34, no. 3, pp. 247-252, 2018, ISSN: 1958-5381 (Electronic) 0767-0974 (Linking), (review).

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2017

Laffont, Sophie; Blanquart, Eve; Guery, Jean-Charles

Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells Journal Article

In: Frontiers in Immunology, vol. 8, pp. 1069, 2017, ISSN: 1664-3224.

Abstract | Links | BibTeX

Laffont, Sophie; Blanquart, Eve; Savignac, Magali; Cenac, Claire; Laverny, Gilles; Metzger, Daniel; Girard, Jean-Philippe; Belz, Gabrielle T; Pelletier, Lucette; Seillet, Cyril; Guery, Jean-Charles

Androgen signaling negatively controls group 2 innate lymphoid cells Journal Article

In: J Exp Med, vol. 214, no. 6, pp. 1581-1592, 2017, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

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Laffont, S.; Seillet, C.; Guery, J. C.

Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function Journal Article

In: Front Immunol, vol. 8, pp. 108, 2017, ISSN: 1664-3224 (Linking).

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Basso, L.; Garnier, L.; Bessac, A.; Boue, J.; Blanpied, C.; Cenac, N.; Laffont, S.; Dietrich, G.

T-lymphocyte-derived enkephalins reduce Th1/Th17 colitis and associated pain in mice Journal Article

In: J Gastroenterol, 2017, ISSN: 1435-5922 (Electronic) 0944-1174 (Linking).

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2015

Griesbeck, M.; Ziegler, S.; Laffont, S.; Smith, N.; Chauveau, L.; Tomezsko, P.; Sharei, A.; Kourjian, G.; Porichis, F.; Hart, M.; Palmer, C. D.; Sirignano, M.; Beisel, C.; Hildebrandt, H.; Cenac, C.; Villani, A. C.; Diefenbach, T. J.; Le Gall, S.; Schwartz, O.; Herbeuval, J. P.; Autran, B.; Guery, J. C.; Chang, J. J.; Altfeld, M.

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-alpha Production in Women Journal Article

In: J Immunol, vol. 195, no. 11, pp. 5327-36, 2015, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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Laffont, S.; Garnier, L.; Lelu, K.; Guery, J. C.

Estrogen-mediated protection of experimental autoimmune encephalomyelitis: Lessons from the dissection of estrogen receptor-signaling in vivo Journal Article

In: Biomed J, vol. 38, no. 3, pp. 194-205, 2015, ISSN: 2320-2890 (Electronic) 2319-4170 (Linking).

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Lupar, E.; Brack, M.; Garnier, L.; Laffont, S.; Rauch, K. S.; Schachtrup, K.; Arnold, S. J.; Guery, J. C.; Izcue, A.

Eomesodermin Expression in CD4+ T Cells Restricts Peripheral Foxp3 Induction Journal Article

In: J Immunol, vol. 195, no. 10, pp. 4742-52, 2015, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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2014

Savignac, M.; Simon, M.; Edir, A.; Guibbal, L.; Hovnanian, A.

SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat Journal Article

In: J Invest Dermatol, vol. 134, no. 7, pp. 1961-1970, 2014, ISSN: 1523-1747 (Electronic) 0022-202X (Linking).

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Laffont, S.; Rouquie, N.; Azar, P.; Seillet, C.; Plumas, J.; Aspord, C.; Guery, J. C.

X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-alpha production of plasmacytoid dendritic cells from women Journal Article

In: J Immunol, vol. 193, no. 11, pp. 5444-52, 2014, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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Mellstrom, B.; Sahun, I.; Ruiz-Nuno, A.; Murtra, P.; Gomez-Villafuertes, R.; Savignac, M.; Oliveros, J. C.; Gonzalez, P.; Kastanauskaite, A.; Knafo, S.; Zhuo, M.; Higuera-Matas, A.; Errington, M. L.; Maldonado, R.; DeFelipe, J.; Jefferys, J. G.; Bliss, T. V.; Dierssen, M.; Naranjo, J. R.

DREAM controls the on/off switch of specific activity-dependent transcription pathways Journal Article

In: Mol Cell Biol, vol. 34, no. 5, pp. 877-87, 2014, ISSN: 1098-5549 (Electronic) 0270-7306 (Linking).

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Lucca, L. E.; Desbois, S.; Ramadan, A.; Ben-Nun, A.; Eisenstein, M.; Carrie, N.; Guery, J. C.; Sette, A.; Nguyen, P.; Geiger, T. L.; Mars, L. T.; Liblau, R. S.

Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice Journal Article

In: J Immunol, vol. 193, no. 7, pp. 3267-77, 2014, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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2013

Pelletier, L.; Savignac, M.

Ca(2+) signaling in T-cell subsets with a focus on the role of cav1 channels: possible implications in therapeutics Journal Article

In: Front Immunol, vol. 4, pp. 150, 2013, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

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Robert, V.; Triffaux, E.; Savignac, M.; Pelletier, L.

Singularities of calcium signaling in effector T-lymphocytes Journal Article

In: Biochim Biophys Acta, vol. 1833, no. 7, pp. 1595-602, 2013, ISSN: 0006-3002 (Print) 0006-3002 (Linking).

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Seillet, C.; Rouquie, N.; Foulon, E.; Douin-Echinard, V.; Krust, A.; Chambon, P.; Arnal, J. F.; Guery, J. C.; Laffont, S.

Estradiol Promotes Functional Responses in Inflammatory and Steady-State Dendritic Cells through Differential Requirement for Activation Function-1 of Estrogen Receptor alpha Journal Article

In: J. Immunol., vol. 190, no. 11, pp. 5459-70, 2013, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

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2012

Pendaries, V.; Gasc, G.; Titeux, M.; Tonasso, L.; Mejia, J. E.; Hovnanian, A.

siRNA-mediated allele-specific inhibition of mutant type VII collagen in dominant dystrophic epidermolysis bullosa Journal Article

In: J Invest Dermatol, vol. 132, no. 6, pp. 1741-3, 2012, ISSN: 1523-1747 (Electronic) 0022-202X (Linking).

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Pernet, C.; Bessis, D.; Savignac, M.; Tron, E.; Guillot, B.; Hovnanian, A.

Genitoperineal papular acantholytic dyskeratosis is allelic to Hailey-Hailey disease Journal Article

In: Br J Dermatol, vol. 167, no. 1, pp. 210-2, 2012, ISSN: 1365-2133 (Electronic) 0007-0963 (Linking).

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Robert, V.; Triffaux, E.; Savignac, M.; Pelletier, L.

[Calcium signaling in T lymphocytes] Journal Article

In: Med Sci (Paris), vol. 28, no. 8-9, pp. 773-9, 2012, ISSN: 0767-0974 (Print) 0767-0974 (Linking).

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Seillet, C.; Laffont, S.; Tremollieres, F.; Rouquie, N.; Ribot, C.; Arnal, J. F.; Douin-Echinard, V.; Gourdy, P.; Guery, J. C.

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling Journal Article

In: Blood, vol. 119, no. 2, pp. 454-64, 2012, ISSN: 1528-0020 (Electronic) 0006-4971 (Linking).

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Guery, J. C.

Estrogens and inflammatory autoimmune diseases Journal Article

In: Joint, bone, spine : revue du rhumatisme, vol. 79, no. 6, pp. 560-2, 2012, ISSN: 1778-7254 (Electronic) 1297-319X (Linking).

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Boue, J.; Blanpied, C.; Djata-Cabral, M.; Pelletier, L.; Vergnolle, N.; Dietrich, G.

Immune conditions associated with CD4+ T effector-induced opioid release and analgesia Journal Article

In: Pain, vol. 153, no. 2, pp. 485-93, 2012, ISSN: 1872-6623 (Electronic) 0304-3959 (Linking).

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Impact on the society

The knowledge of the biological mechanisms underlying the sex differences in immunity is of fundamental importance with potential significant impacts for the management of patients suffering from autoimmune, infectious diseases, or allergy.

This research area has been largely under-studied for many years despite societal demand and the numerous clinical, epidemiological and experimental observations highlighting a major role of sex in the susceptibility, severity and magnitude of numerous immuno- pathological, whether in autoimmune (MAI) and infectious diseases, allergy and anti-tumor immunity.

In recent years, this area has gained increasing interest, particularly following the recommendations of the NIH in 2015, prompting recognition of sex as a biological variable in preclinical studies in order to improve the rigor and reproducibility of research.

Alumni

PhD

  • Gilles Foucras, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 1997-2000.
    Now Full Professor at Ecole Nationale Vétérinaire de Toulouse, France
  • Jérôme Coudert, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 1998-2002
    Now Research Officer, Lions Eyes Institute, Perth, Australia
  • Lucile Garidou, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2002-2005
    Now Research Officer, Pierre Fabre, Toulouse
  • Sophie Laffont, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2003-2007
    Now post-doctoral fellow, University of Geneva, Switzerland
  • Abdallah Badou, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 1994-1998
    Now assistant Professor at the University of Safi, Marocco
  • Bruno Gomes diplôme de de Doctorat en Immunologie, Université Paul Sabatier, 2003-2005
    Head, Tumor Immunology, ITEOS THERAPEUTICS, Gosselies, Belgium
  • Marilena Djata Cabral diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2004-2008
    Teaching Organizer Université Virtuelle Africaine, Nairobi, Kenya
  • Karine Lélu, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2006-2010
    Now Research Officer, Transgene, Illkirch, France
  • Cyril Seillet, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2007-2011
    Now post-doctoral fellow, WEHI, Melbourne, Australia
  • Virginie Robert- Gavioli Diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2008-2012
    Now post-doctoral fellow at Stromalab, Toulouse
  • Emily Triffaux, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2010-2013
    Now Medical Science Liaison Thrombosis Benelux, LEO Pharma, Belgium
  • Pascal Azar, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2012-2016
    Now assistant Professor at the University of Lebanon
  • Laure Garnier, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2012-2016
    Now post-doctoral fellow, University of Geneva, Switzerland
  • Nicolas Rosa, diplôme de Doctorat en Immunologie, Université Paul Sabatier, 2014-2017

 

Post-doc

  • Laurent Delpy, INSERM U563, CPTP, Toulouse (2002-2006)
    Now DR2 CNRS, CNRS UMR7276 CRIBL, Limoges, France
  • Victorine Douin, INSERM U563, CPTP, Toulouse (2003-2004)
    Now assistant Professor (MCU-PH) at the University of Toulouse, France

Partenaires Equipe 3

CNRS

CNRS

Région Occitanie

Région Occitanie

ARSEP

ARSEP

ARTHRITIS

ARTHRITIS

Fondation de recherche médicale

Fondation de recherche médicale

Société Française d’Allergologie

Société Française d’Allergologie

CSL Behring

CSL Behring

ANRS

ANRS

Sidaction

Sidaction

ATIP AVENIR

ATIP AVENIR