Asthma, Allergy and Immunotherapy

Coordinator : L. Reber

Scientific objectives


Allergies are major public health problems of increasing prevalence. The World Health Organization (WHO) indicates that 50% people will suffer from at least one type of allergy in 2050.

Our research focuses on deciphering the cellular and molecular mechanisms of allergies, in order to identify potential new therapeutic targets. To assess this, we use in vivo models of allergies (allergic asthma, food allergy, anaphylaxis, atopic dermatitis), combined with the use of clinical samples from allergic patients, in collaboration with clinical teams of Toulouse university hospital. We are also specialized in preclinical and clinical development of immunotherapies for allergic diseases.

 

Our projects


Decipher the cellular and molecular mechanisms of allergic shock reactions (anaphylaxis)

Allergic shock, also known as anaphylaxis, is a rapid and systemic allergic reaction which can be fatal. The current paradigm states that in human, anaphylaxis is mostly triggered by allergen-specific IgE antibodies. Upon exposure to an allergen in sensitized patients, such allergen is recognized by IgE bound to their receptor on the surface of mast cells, which lead to the activation of mast cells and the release of histamine responsible for most clinical signs of anaphylaxis. Anaphylaxis represents an emergency situation for the medical staff, which makes the study of the mechanisms of human anaphylaxis very difficult. For this reason, several mouse models of anaphylaxis have been generated and used to gain insight into the mechanisms of this allergic reaction.

Our previous results show that, in mice, two main pathways of anaphylaxis coexist : a “classical” pathway induced by IgE antibodies, mast cells and histamine, and an “alternative” pathway induced by IgG antibodies which can activate myeloid cells, leading to the release of platelet-activating factor (PAF). Our research aims at demonstrating that these classical and alternative pathways also coexist in human anaphylaxis. To do so, we use clinical samples from allergic patients, combined with humanized mouse models which allow us to directly assess the mechanisms of anaphylaxis induced by human antibodies.

Development of new immunotherapies for allergic diseases

Allergies are major public health problems for which there is, in most cases, no efficient long-term therapy. The main goal of our research is to develop new immunotherapies which could induce efficient and long-term protection against allergies. We focus on both passive (therapeutic monoclonal antibodies) and active immunotherapies (allergen-specific immunotherapies and vaccine approaches). We use in vivo models of major allergies (asthma, food allergy, anaphylaxis and atopic dermatitis) to test the efficiency of these passive and active immunotherapeutic approaches. In addition, some of the validated immunotherapies are used by the clinicians of our team to treat allergic patients.

Clinical research in severe asthma

The vision of asthma has dramatically changed over the past ten years. This entity is not consider a single disease but encompasses a heterogeneous group of diseases. Asthma in obese subjects is characterized by more severe symptoms and is more difficult to control in clinical practice. An interregional Hospital Clinical Research Project (PHRC) has recently been accepted to study the effect of intragastric balloons in uncontrolled obese asthmatics. Our team is widely involved in academic and industrial clinical trials in severe asthma. We share the coordination, together with the Nantes team, of a network called CRISALIS (Severe Asthma Clinical Research Initiative: a lever for innovation and science) supported by F-CRIN (French Network for Clinical Research Infrastructure) (INSERM). Clinical teams from 11 teaching hospitals work altogether in this network which greatly improve clinical research in severe asthma in France. We are particularly responsible for the group on the role of obesity and other comorbidities in severe asthma.

Other informations


Publications

2023

Guilleminault, Laurent; Villeneuve, Thomas; Didier, Alain; Reber, Laurent L; Sigfried, Aurore; Serrano, Elie; de Bonnecaze, Guillaume

Maintained effect of endoscopic sinus surgery in asthma responders to drugs targeting the IL5 pathway with persistent nasal polyposis Miscellaneous

2023, ISSN: 1398-9995.

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Croote, Derek; Wong, Joyce J W; Pecalvel, Cyprien; Leveque, Edouard; Casanovas, Natacha; Kamphuis, Jasper B J; Creeks, Paige; Romero, Johanna; Sohail, Saba; Bedinger, Daniel; Nadeau, Kari C; Chinthrajah, Rebecca S; Reber, Laurent L; Lowman, Henry B

Widespread monoclonal IgE antibody convergence to an immunodominant, proanaphylactic Ara h 2 epitope in peanut allergy Journal Article

In: J Allergy Clin Immunol, 2023, ISSN: 1097-6825.

Abstract | Links | BibTeX

Tauber#, Marie; Basso#, Lilian; Martin#, Jeremy; Bostan, Luciana; Pinto, Marlene Magalhaes; Thierry, Guilhem R; Houmadi, Raïssa; Serhan, Nadine; Loste, Alexia; Blériot, Camille; Kamphuis, Jasper B J; Grujic, Mirjana; Kjellén, Lena; Pejler, Gunnar; Paul, Carle; Dong, Xinzhong; Galli, Stephen J; Reber, Laurent L; Ginhoux, Florent; Bajenoff, Marc; Gentek, Rebecca; Gaudenzio, Nicolas

Landscape of mast cell populations across organs in mice and humans Journal Article

In: Journal of Experimental Medicine, 2023.

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P, Lifar; F, Montastruc; LL, Reber; JF, Magnaval; L, Guilleminault

Parasitic Infections and Biological Therapies Targeting Type 2 Inflammation: A VigiBase Study Journal Article

In: 2023.

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J, Stackowicz; CM, Gillis; O, Godon; B, Iannascoli; E, Conde; E, Leveque; WPM, Worrall; SJ, Galli; P, Bruhns; LL, Reber; F, Jönsson

Conditional neutrophil depletion challenges their contribution to mouse models of anaphylaxis. Journal Article

In: Allergy, 2023.

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E, Lamanna; E, Conde; A, Mougel; J, Bonnefoy; F, Colaone; O, Godon; S, Hamdi; JBJ, Kamphuis; B, Drouet; V, Serra; P, Bruhns; LL, Reber

A vaccine targeting human IL-4 and IL-13 protects against asthma in humanized mice. Journal Article

In: Allergy, 2023.

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2022

B, Todorova; O, Godon; E, Conde; CM, Gillis; B, Iannascoli; O, Richard-Le Goff; D, Fiole; LT, Roumenina; JHW, Leusen; AJ, Murphy; LE, Macdonald; LL, Reber; F, Jönsson; P, Bruhns

IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice. Journal Article

In: J Immunol, 2022.

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Kamphuis JBJ Worrall WPM, Stackowicz J

The anti-FcεRI antibody MAR-1 depletes basophils and cross-reacts with myeloid cells through its Fc portion Journal Article

In: Allergy, vol. 77, no. 6, pp. 1903-1906, 2022.

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JBJ, Kamphuis; LL, Reber; H, Eutamène; V, Theodorou

Increased fermentable carbohydrate intake alters colonic mucus barrier function through glycation processes and increased mast cell counts. Journal Article

In: FASEB J, 2022.

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L, Guilleminault; E, Conde; LL., Reber

Pharmacological approaches to target type 2 cytokines in asthma. Journal Article

In: Pharmacol Ther, 2022.

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L, Guilleminault; M, Mounié; A, Sommet; C, Camus; A, Didier; LL, Reber; N, Costa; C, Conte

Healthcare resource consumption prior to asthma-related death: a nationwide descriptive study. Journal Article

In: Ther Adv Respir Dis, 2022.

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Lauret, S.; Noel-Savina, E.; Prevot, G.; Guibert, N.; Reber, L.; Brouquieres, D.; Didier, A.; Guilleminault, L.

Are serum immunoglobulin concentrations a predictive biomarker of response to anti-IL5/IL5Ralpha therapies? Journal Article

In: Respir Med Res, vol. 81, pp. 100882, 2022, ISSN: 2590-0412 (Electronic) 2590-0412 (Linking).

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Guilleminault, L.; Michelet, M.; Reber, L. L.

Combining Anti-IgE Monoclonal Antibodies and Oral Immunotherapy for the Treatment of Food Allergy Journal Article

In: Clin Rev Allergy Immunol, vol. 62, no. 1, pp. 216-231, 2022, ISSN: 1559-0267 (Electronic) 1080-0549 (Linking).

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2021

Bertrand R Conde E, Balbino B

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice Journal Article

In: Nature Communications, vol. 12, no. 1, pp. 2574, 2021.

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Gaudenzio N Starkl P, Marichal T

IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells Journal Article

In: Allergy, 2021.

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Worrall WPM Kamphuis JBJ, Stackowicz J

Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression" Journal Article

In: Science, vol. 372, no. 6538, pp. eabf2022., 2021.

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Balbino B Michelet M, Guilleminault L

IgE in the pathophysiology and therapy of food allergy Journal Article

In: European Journal of Immunology, vol. 51, no. 3, pp. 531-543, 2021.

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Montastruc F Quinta JB, Sommet A

Cardiovascular adverse effects of anti-IL-5/IL-5Rα therapies: A real-world study Journal Article

In: J Allergy Clin Immunol Pract, vol. 9, no. 3, pp. 1411-1413, 2021.

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Stackowicz, J.; Gaudenzio, N.; Serhan, N.; Conde, E.; Godon, O.; Marichal, T.; Starkl, P.; Balbino, B.; Roers, A.; Bruhns, P.; Jonsson, F.; Moguelet, P.; Georgin-Lavialle, S.; Broderick, L.; Hoffman, H. M.; Galli, S. J.; Reber, L. L.

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome Journal Article

In: J Exp Med, vol. 218, no. 10, 2021, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

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Conde, E.; Bruhns, P.; Serra, V.; Reber, L. L.

Development and preclinical evaluation of a vaccine targeting IL-4 and IL-13 for the treatment of allergic asthma Journal Article

In: Allergy, vol. 76, no. 11, pp. 3553-3555, 2021, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Conde, E.; Bertrand, R.; Balbino, B.; Bonnefoy, J.; Stackowicz, J.; Caillot, N.; Colaone, F.; Hamdi, S.; Houmadi, R.; Loste, A.; Kamphuis, J. B. J.; Huetz, F.; Guilleminault, L.; Gaudenzio, N.; Mougel, A.; Hardy, D.; Snouwaert, J. N.; Koller, B. H.; Serra, V.; Bruhns, P.; Grouard-Vogel, G.; Reber, L. L.

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice Journal Article

In: Nat Commun, vol. 12, no. 1, pp. 2574, 2021, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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2020

Starkl, Philipp; Watzenboeck, Martin L; Popov, Lauren M; Zahalka, Sophie; Hladik, Anastasiya; Lakovits, Karin; Radhouani, Mariem; Haschemi, Arvand; Marichal, Thomas; Reber, Laurent L; Gaudenzio, Nicolas; Sibilano, Riccardo; Stulik, Lukas; Fontaine, Frédéric; Mueller, André C; Amieva, Manuel R; Galli, Stephen J; Knapp, Sylvia

IgE Effector Mechanisms, in Concert with Mast Cells, Contribute to Acquired Host Defense against Staphylococcusaureus. Journal Article

In: Immunity, vol. 53, no. 4, pp. 793–804.e9, 2020, ISSN: 1097-4180 (Electronic).

Abstract | Links | BibTeX

Guibert, N; Guilleminault, L; Lepage, B; Heluain, V; Fumat, R; Dupuis, M; Faviez, G; Plat, G; Hermant, C; Didier, A

Bronchial thermoplasty in patients with dynamic hyperinflation: Results from the proof-of-concept HEAT trial Journal Article

In: Eur Respir J., 2020.

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Dupin, C; Belhadi, D; Guilleminault, L; Gamez, A S; Berger, P; De Blay, F.; Bonniaud, P; Leroyer, C; Mahay, G; Girodet, P O; Raherison, C; Fry, S; Le Bourdellès, G.; Proust, A; Rosencher, L; Garcia, G; Bourdin, A; Chenivesse, C; Didier, A; Couffignal, C; Taillé, C

Effectiveness and safety of dupilumab for the treatment of severe asthma in a real-life French multi-centre adult cohort. Journal Article

In: Clin Exp Allergy, vol. 50, no. 7, pp. 789-798, 2020.

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Descazeaux, M; Brouquières, D; Didier, A; Lescouzères, M; Napoléon, M F; Escamilla, R; Guilleminault, L

Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough. Journal Article

In: Lung, vol. 198, no. 3, pp. 441-448, 2020.

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Goyard, S; Balbino, B; Chinthrajah, R S; Lyu, S C; Janin, Y L; Bruhns, P; Poncet, P; Galli, S J; Nadeau, K C; Reber, L L; Rose, T

A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples. Journal Article

In: Allergy, 2020.

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Balbino, B; Herviou, P; o Godon,; Stackowicz, J; Goff, O R; Iannascoli, B; Sterlin, D; Brûlé, S; Millot, G A; Harris, F M; Voronina, V A; Nadeau, K C; Macdonald, L E; Murphy, A J; Bruhns, P; Reber, L L

The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors. Journal Article

In: J Clin Invest, vol. 130, no. 3, pp. 1330-1335, 2020.

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Stackowicz, J.; Jönsson, F.; Reber, L L.

Mouse Models and Tools for the in vivo Study of Neutrophils. Journal Article

In: Frony Immunol, 2020.

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Dardé, X.; Mailhol, C.; Migueres, I.; Didier, A.; Guilleminault, L.

Overweight and bronchospasm during general anaesthesia: An association with heterogeneous mechanisms. Journal Article

In: Allergol Int, vol. S1323-8930, no. 20, 2020.

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Gruzelle, V.; C., Mailhol; W., Waters D; L., Guilleminault

Clinical Utility of Rush Venom Immunotherapy: Current Status. Journal Article

In: J Asthma Allergy, vol. 13, pp. 1-10, 2020.

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2019

Serhan, N.; Basso, L.; Sibilano, R.; Petitfils, C.; Meixiong, J.; Bonnart, C.; Reber, L L.; Marichal, T.; Starkl, P.; Cenac, N.; Dong, X.; Tsai, M.; Galli, S J.; Gaudenzio, N.

House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation Journal Article

In: Nat Immunol, vol. 20, no. 11, pp. 1435-1443, 2019.

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Wang, Q; Lepus, C M; Raghu, H; Reber, L L; Tsai, M M; Wong, H H; von Kaeppler, E; Lingampalli, N; Bloom, M S; Hu, N; Elliott, E E; Oliviero, F; Punzi, L; Giori, N J; Goodman, S B; Chu, C R; Sokolove, J; Fukuoka, Y; Schwartz, L B; Galli, S J; Robinson, W H

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis. Journal Article

In: Elife, 2019.

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Verduyn, M.; Botto, G.; Jaubert, J.; Lier, C.; Flament, T.; Guilleminault, L.

Serum IgG concentrations in adult patients experiencing virus-induced severe asthma exacerbations Journal Article

In: J Allergy Clin Immunol Pract, 2019, ISSN: 2213-2201 (Electronic).

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Piliponsky, A. M.; Shubin, N. J.; Lahiri, A. K.; Truong, P.; Clauson, M.; Niino, K.; Tsuha, A. L.; Nedospasov, S. A.; Karasuyama, H.; Reber, L. L.; Tsai, M.; Mukai, K.; Galli, S. J.

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice Journal Article

In: Nat Immunol, vol. 20, no. 2, pp. 129-140, 2019, ISSN: 1529-2916 (Electronic) 1529-2908 (Linking).

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2018

Mailhol, C.; Delcourt, N.; Apoil, P. A.; Didier, A.; Franchitto, N.

Are changes necessary in the medical management of a patient with snakebite regarding the incidence of hypersensitivity reaction to antivenom polyvalent immune fab? Journal Article

In: Clin Toxicol (Phila), vol. 56, no. 4, pp. 310-311, 2018, ISSN: 1556-9519 (Electronic) 1556-3650 (Linking).

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Stackowicz, J.; Balbino, B.; Todorova, B.; Godon, O.; Iannascoli, B.; Jonsson, F.; Bruhns, P.; Reber, L. L.

Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction Journal Article

In: Nat Commun, vol. 9, no. 1, pp. 2304, 2018, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Seguro, F.; Bard, V.; Sedkaoui, K.; Riche, M.; Didier, A.; Bouhanick, B.

Screening obstructive sleep apnea-hypopnea syndrome in hypertensive patients: a comparative study of the efficiency of the Epworth sleepiness scale Journal Article

In: BMC Pulm Med, vol. 18, no. 1, pp. 173, 2018, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Secher, T.; Guilleminault, L.; Reckamp, K.; Amanam, I.; Plantier, L.; Heuze-Vourc'h, N.

Therapeutic antibodies: A new era in the treatment of respiratory diseases? Journal Article

In: Pharmacol Ther, vol. 189, pp. 149-172, 2018, ISSN: 1879-016X (Electronic) 0163-7258 (Linking).

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Balbino, B.; Conde, E.; Marichal, T.; Starkl, P.; Reber, L. L.

Approaches to target IgE antibodies in allergic diseases Journal Article

In: Pharmacol Ther, vol. 191, pp. 50-64, 2018, ISSN: 1879-016X (Electronic) 0163-7258 (Linking).

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Humbert, M.; Taille, C.; Mala, L.; Le Gros, V.; Just, J.; Molimard, M.; investigators, Stellair

Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study Journal Article

In: Eur Respir J, vol. 51, no. 5, 2018, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Hachulla, E.; Jais, X.; Cinquetti, G.; Clerson, P.; Rottat, L.; Launay, D.; Cottin, V.; Habib, G.; Prevot, G.; Chabanne, C.; Fois, E.; Amoura, Z.; Mouthon, L.; Le Guern, V.; Montani, D.; Simonneau, G.; Humbert, M.; Sobanski, V.; Sitbon, O.; French Collaborators Recruiting, Members

Pulmonary Arterial Hypertension Associated With Systemic Lupus Erythematosus: Results From the French Pulmonary Hypertension Registry Journal Article

In: Chest, vol. 153, no. 1, pp. 143-151, 2018, ISSN: 1931-3543 (Electronic) 0012-3692 (Linking).

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Guilleminault, L.; Rolland, Y.; Didier, A.

[Characteristics of non-pharmacological interventions in the elderly with COPD. Smoking cessation, pulmonary rehabilitation, nutritional management and patient education] Journal Article

In: Rev Mal Respir, vol. 35, no. 6, pp. 626-641, 2018, ISSN: 1776-2588 (Electronic) 0761-8425 (Linking).

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Guibert, N.; Mhanna, L.; Didier, A.; Moreno, B.; Leyx, P.; Plat, G.; Mazieres, J.; Hermant, C.

Integration of 3D printing and additive manufacturing in the interventional pulmonologist's toolbox Journal Article

In: Respir Med, vol. 134, pp. 139-142, 2018, ISSN: 1532-3064 (Electronic) 0954-6111 (Linking).

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Gruzelle, V.; Ramassamy, M.; Bulai Lidiveanu, C.; Didier, A.; Mailhol, C.; Guilleminault, L.

Safety of ultra-rush protocols for hymenoptera venom immunotherapy in systemic mastocytosis Journal Article

In: Allergy, vol. 73, no. 11, pp. 2260-2263, 2018, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Gillis, C. M.; Reber, L. L.

[PMN(DTR) mice: a new model to study neutrophils in vivo] Journal Article

In: Med Sci (Paris), vol. 34, no. 4, pp. 339-343, 2018, ISSN: 1958-5381 (Electronic) 0767-0974 (Linking).

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Gaudenzio, N.; Marichal, T.; Galli, S. J.; Reber, L. L.

Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity Journal Article

In: Front Immunol, vol. 9, pp. 1275, 2018, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

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Dupuis, M.; Noel-Savina, E.; Prevot, G.; Tetu, L.; Pillard, F.; Riviere, D.; Didier, A.

Determination of Cardiac Output in Pulmonary Hypertension Using Impedance Cardiography Journal Article

In: Respiration, vol. 96, no. 6, pp. 500-506, 2018, ISSN: 1423-0356 (Electronic) 0025-7931 (Linking).

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Droneau, S.; Noel-Savina, E.; Plat, G.; Murris-Espin, M.; Leborgne-Krams, A.; Brouchet, L.; Dahan, M.; Didier, A.

Use of Ultrasonography for Lung Transplant Recipients on Postoperative Care Journal Article

In: J Ultrasound Med, 2018, ISSN: 1550-9613 (Electronic) 0278-4297 (Linking).

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Boghanim, T.; Murris, M.; Lamon, T.; Huynh, A.; Mazieres, J.; Marquette, C. H.; Didier, A.

Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation Journal Article

In: Lung, 2018, ISSN: 1432-1750 (Electronic) 0341-2040 (Linking).

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2017

Balbino, B.; Sibilano, R.; Starkl, P.; Marichal, T.; Gaudenzio, N.; Karasuyama, H.; Bruhns, P.; Tsai, M.; Reber, L. L.; Galli, S. J.

Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis Journal Article

In: J Allergy Clin Immunol, vol. 139, no. 2, pp. 584-596 e10, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Reber, L. L.; Starkl, P.; Balbino, B.; Sibilano, R.; Gaudenzio, N.; Rogalla, S.; Sensarn, S.; Kang, D.; Raghu, H.; Sokolove, J.; Robinson, W. H.; Contag, C. H.; Tsai, M.; Galli, S. J.

The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice Journal Article

In: PLoS One, vol. 12, no. 10, pp. e0185704, 2017, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

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Reber, L. L.; Sibilano, R.; Starkl, P.; Roers, A.; Grimbaldeston, M. A.; Tsai, M.; Gaudenzio, N.; Galli, S. J.

Imaging protective mast cells in living mice during severe contact hypersensitivity Journal Article

In: JCI Insight, vol. 2, no. 9, 2017, ISSN: 2379-3708 (Electronic) 2379-3708 (Linking).

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Reber, L. L.; Hernandez, J. D.; Galli, S. J.

The pathophysiology of anaphylaxis Journal Article

In: J Allergy Clin Immunol, vol. 140, no. 2, pp. 335-348, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Reber, L. L.; Gillis, C. M.; Starkl, P.; Jonsson, F.; Sibilano, R.; Marichal, T.; Gaudenzio, N.; Berard, M.; Rogalla, S.; Contag, C. H.; Bruhns, P.; Galli, S. J.

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide Journal Article

In: J Exp Med, vol. 214, no. 5, pp. 1249-1258, 2017, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

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Guibert, N.; Didier, A.; Moreno, B.; Mhanna, L.; Brouchet, L.; Plat, G.; Hermant, C.; Mazieres, J.

Treatment of Post-transplant Complex Airway Stenosis with a Three-Dimensional, Computer-assisted Customized Airway Stent Journal Article

In: Am J Respir Crit Care Med, vol. 195, no. 7, pp. e31-e33, 2017, ISSN: 1535-4970 (Electronic) 1073-449X (Linking).

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Guilleminault, L.; Ouksel, H.; Belleguic, C.; Le Guen, Y.; Germaud, P.; Desfleurs, E.; Leroyer, C.; Magnan, A.

Personalised medicine in asthma: from curative to preventive medicine Journal Article

In: Eur Respir Rev, vol. 26, no. 143, 2017, ISSN: 1600-0617 (Electronic) 0905-9180 (Linking).

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Guilleminault, L.; Viala-Gastan, C.

[Blomia tropicalis: A house dust mite in the tropics] Journal Article

In: Rev Mal Respir, vol. 34, no. 8, pp. 791-801, 2017, ISSN: 1776-2588 (Electronic) 0761-8425 (Linking).

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Guilleminault, L.; Williams, E. J.; Scott, H. A.; Berthon, B. S.; Jensen, M.; Wood, L. G.

Diet and Asthma: Is It Time to Adapt Our Message? Journal Article

In: Nutrients, vol. 9, no. 11, 2017, ISSN: 2072-6643 (Electronic) 2072-6643 (Linking).

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Joulia, R.; Mailhol, C.; Valitutti, S.; Didier, A.; Espinosa, E.

Direct monitoring of basophil degranulation by using avidin-based probes Journal Article

In: J Allergy Clin Immunol, vol. 140, no. 4, pp. 1159-1162 e6, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Guibert, N.; Moreno, B.; Plat, G.; Didier, A.; Mazieres, J.; Hermant, C.

Stenting of Complex Malignant Central-Airway Obstruction Guided by a Three-Dimensional Printed Model Of The Airways Journal Article

In: Ann Thorac Surg, vol. 103, no. 4, pp. e357-e359, 2017, ISSN: 1552-6259 (Electronic) 0003-4975 (Linking).

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Morelot-Panzini, C.; Adler, D.; Aguilaniu, B.; Allard, E.; Bautin, N.; Beaumont, M.; Blanc, F. X.; Chenivesse, C.; Dangers, L.; Delclaux, C.; Demoule, A.; Devillier, P.; Didier, A.; Georges, M.; Housset, B.; Janssens, J. P.; Laveneziana, P.; Laviolette, L.; Muir, J. F.; Ninot, G.; Perez, T.; Peiffer, C.; Schmidt, M.; Similowski, T.; Straus, C.; Taille, C.; Van Den Broecke, S.; Roche, N.; dyspnoea working group of the Societe de Pneumologie de Langue, Francaise

Breathlessness despite optimal pathophysiological treatment: on the relevance of being chronic Journal Article

In: Eur Respir J, vol. 50, no. 3, 2017, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Paganin, F.; Mangiapan, G.; Proust, A.; Prudhomme, A.; Attia, J.; Marchand-Adam, S.; Pellet, F.; Milhe, F.; Melloni, B.; Bernady, A.; Raspaud, C.; Nocent, C.; Berger, P.; Guilleminault, L.

Lung function parameters in omalizumab responder patients: An interesting tool? Journal Article

In: Allergy, vol. 72, no. 12, pp. 1953-1961, 2017, ISSN: 1398-9995 (Electronic) 0105-4538 (Linking).

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Chavoin, J. P.; Dahan, M.; Savina, E. N.; Didier, A.; Chaput, B.

Reply: Correction of Pectus Excavatum by Custom-Made Silicone Implants: Contribution of Computer-Aided Design Reconstruction. A 20-Year Experience and 401 Cases Journal Article

In: Plast Reconstr Surg, vol. 139, no. 1, pp. 325e-326e, 2017, ISSN: 1529-4242 (Electronic) 0032-1052 (Linking).

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Casale, T. B.; Cox, L. S.; Wahn, U.; Golden, D. B. K.; Bons, B.; Didier, A.

Safety Review of 5-Grass Pollen Tablet from Pooled Data of Clinical Trials Journal Article

In: J Allergy Clin Immunol Pract, vol. 5, no. 6, pp. 1717-1727 e1, 2017, ISSN: 2213-2201 (Electronic).

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Beutier, H.; Gillis, C. M.; Iannascoli, B.; Godon, O.; England, P.; Sibilano, R.; Reber, L. L.; Galli, S. J.; Cragg, M. S.; Van Rooijen, N.; Mancardi, D. A.; Bruhns, P.; Jonsson, F.

IgG subclasses determine pathways of anaphylaxis in mice Journal Article

In: J Allergy Clin Immunol, vol. 139, no. 1, pp. 269-280 e7, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Beau, A. B.; Didier, A.; Hurault-Delarue, C.; Montastruc, J. L.; Lacroix, I.; Damase-Michel, C.

Prescription of asthma medications before and during pregnancy in France: An observational drug study using the EFEMERIS database Journal Article

In: J Asthma, vol. 54, no. 3, pp. 258-264, 2017, ISSN: 1532-4303 (Electronic) 0277-0903 (Linking).

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2016

Dupin, C.; Marchand-Adam, S.; Favelle, O.; Costes, R.; Gatault, P.; Diot, P.; Grammatico-Guillon, L.; Guilleminault, L.

Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation Journal Article

In: J Clin Immunol, vol. 36, no. 8, pp. 810-817, 2016, ISSN: 1573-2592 (Electronic) 0271-9142 (Linking).

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Flament, T.; Marchand-Adam, S.; Gatault, P.; Dupin, C.; Diot, P.; Guilleminault, L.

What are the characteristics of asthma patients with elevated serum IgG4 levels? Journal Article

In: Respir Med, vol. 112, pp. 39-44, 2016, ISSN: 1532-3064 (Electronic) 0954-6111 (Linking).

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Gaudenzio, N.; Sibilano, R.; Marichal, T.; Starkl, P.; Reber, L. L.; Cenac, N.; McNeil, B. D.; Dong, X.; Hernandez, J. D.; Sagi-Eisenberg, R.; Hammel, I.; Roers, A.; Valitutti, S.; Tsai, M.; Espinosa, E.; Galli, S. J.

Different activation signals induce distinct mast cell degranulation strategies Journal Article

In: J Clin Invest, vol. 126, no. 10, pp. 3981-3998, 2016, ISSN: 1558-8238 (Electronic) 0021-9738 (Linking).

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Guilleminault, L.; Just, J.; Humbert, M.; Leroyer, C.; Epaud, R.

[Seasonality in asthma: Impact and treatments] Journal Article

In: Presse Med, vol. 45, no. 11, pp. 1005-1018, 2016, ISSN: 2213-0276 (Electronic) 0755-4982 (Linking).

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Guibert, N.; Mazieres, J.; Didier, A.; Porte, S. J.; Projetti, F.; Hermant, C.

Tracheal Glomangioleiomyoma Treated by Multimodal Interventional Bronchoscopy Journal Article

In: Ann Thorac Surg, vol. 101, no. 4, pp. 1591-4, 2016, ISSN: 1552-6259 (Electronic) 0003-4975 (Linking).

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Cox, L. S.; Didier, A.; Demoly, P.; Wahn, U.; Pradalier, A.; Frew, A. J.; Devillier, P.

Methodological aspects of a meta-analysis of grass pollen allergen sublingual immunotherapy tablets Journal Article

In: J Allergy Clin Immunol, vol. 138, no. 1, pp. 314-315 e4, 2016, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Guibert, N.; Mhanna, L.; Droneau, S.; Plat, G.; Didier, A.; Mazieres, J.; Hermant, C.

Techniques of endoscopic airway tumor treatment Journal Article

In: J Thorac Dis, vol. 8, no. 11, pp. 3343-3360, 2016, ISSN: 2072-1439 (Print) 2072-1439 (Linking).

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Reber, L. L.; Gaudenzio, N.; Starkl, P.; Galli, S. J.

Neutrophils are not required for resolution of acute gouty arthritis in mice Journal Article

In: Nat Med, vol. 22, no. 12, pp. 1382-1384, 2016, ISSN: 1546-170X (Electronic) 1078-8956 (Linking).

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Bousquet, J.; Schunemann, H. J.; Hellings, P. W.; Arnavielhe, S.; Bachert, C.; Bedbrook, A.; Bergmann, K. C.; Bosnic-Anticevich, S.; Brozek, J.; Calderon, M.; Canonica, G. W.; Casale, T. B.; Chavannes, N. H.; Cox, L.; Chrystyn, H.; Cruz, A. A.; Dahl, R.; De Carlo, G.; Demoly, P.; Devillier, P.; Dray, G.; Fletcher, M.; Fokkens, W. J.; Fonseca, J.; Gonzalez-Diaz, S. N.; Grouse, L.; Keil, T.; Kuna, P.; Larenas-Linnemann, D.; Lodrup Carlsen, K. C.; Meltzer, E. O.; Mullol, J.; Muraro, A.; Naclerio, R. N.; Palkonen, S.; Papadopoulos, N. G.; Passalacqua, G.; Price, D.; Ryan, D.; Samolinski, B.; Scadding, G. K.; Sheikh, A.; Spertini, F.; Valiulis, A.; Valovirta, E.; Walker, S.; Wickman, M.; Yorgancioglu, A.; Haahtela, T.; Zuberbier, T.; group*, Mask study

MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis Journal Article

In: J Allergy Clin Immunol, vol. 138, no. 2, pp. 367-374 e2, 2016, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Guilleminault, L.; Laurent, S.; Foucher, A.; Poubeau, P.; Paganin, F.

Pulmonary arterial hypertension in adult onset Still's disease: a case report of a severe complication Journal Article

In: BMC Pulm Med, vol. 16, no. 1, pp. 72, 2016, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Sibilano, R.; Gaudenzio, N.; DeGorter, M. K.; Reber, L. L.; Hernandez, J. D.; Starkl, P. M.; Zurek, O. W.; Tsai, M.; Zahner, S.; Montgomery, S. B.; Roers, A.; Kronenberg, M.; Yu, M.; Galli, S. J.

A TNFRSF14-FcvarepsilonRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice Journal Article

In: Nat Commun, vol. 7, pp. 13696, 2016, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Reber, L. L.; Fahy, J. V.

Mast cells in asthma: biomarker and therapeutic target Journal Article

In: Eur Respir J, vol. 47, no. 4, pp. 1040-2, 2016, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Rabeau, A.; Mazieres, J.; Hermant, C.; Projetti, F.; Didier, A.; Guibert, N.

Bronchoscopic Multimodal Management of Tracheal Neurofibroma Journal Article

In: J Bronchology Interv Pulmonol, vol. 23, no. 4, pp. 340-342, 2016, ISSN: 1948-8270 (Electronic) 1948-8270 (Linking).

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Respaud, R.; Marchand, D.; Pelat, T.; Tchou-Wong, K. M.; Roy, C. J.; Parent, C.; Cabrera, M.; Guillemain, J.; Mac Loughlin, R.; Levacher, E.; Fontayne, A.; Douziech-Eyrolles, L.; Junqua-Moullet, A.; Guilleminault, L.; Thullier, P.; Guillot-Combe, E.; Vecellio, L.; Heuze-Vourc'h, N.

Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin Journal Article

In: J Control Release, vol. 234, pp. 21-32, 2016, ISSN: 1873-4995 (Electronic) 0168-3659 (Linking).

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Starkl, P.; Marichal, T.; Gaudenzio, N.; Reber, L. L.; Sibilano, R.; Tsai, M.; Galli, S. J.

IgE antibodies, FcepsilonRIalpha, and IgE-mediated local anaphylaxis can limit snake venom toxicity Journal Article

In: J Allergy Clin Immunol, vol. 137, no. 1, pp. 246-257 e11, 2016, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Morelot-Panzini, C.; Gilet, H.; Aguilaniu, B.; Devillier, P.; Didier, A.; Perez, T.; Pignier, C.; Arnould, B.; Similowski, T.

Real-life assessment of the multidimensional nature of dyspnoea in COPD outpatients Journal Article

In: Eur Respir J, vol. 47, no. 6, pp. 1668-79, 2016, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Marichal, T.; Gaudenzio, N.; El Abbas, S.; Sibilano, R.; Zurek, O.; Starkl, P.; Reber, L. L.; Pirottin, D.; Kim, J.; Chambon, P.; Roers, A.; Antoine, N.; Kawakami, Y.; Kawakami, T.; Bureau, F.; Tam, S. Y.; Tsai, M.; Galli, S. J.

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis Journal Article

In: J Clin Invest, vol. 126, no. 12, pp. 4497-4515, 2016, ISSN: 1558-8238 (Electronic) 0021-9738 (Linking).

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Laforest, L.; Belhassen, M.; Devouassoux, G.; Didier, A.; Ginoux, M.; Van Ganse, E.

Long-Term Inhaled Corticosteroid Adherence in Asthma Patients with Short-Term Adherence Journal Article

In: J Allergy Clin Immunol Pract, vol. 4, no. 5, pp. 890-899 e2, 2016, ISSN: 2213-2201 (Electronic).

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2015

Gaudenzio, N.; Sibilano, R.; Starkl, P.; Tsai, M.; Galli, S. J.; Reber, L. L.

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice Journal Article

In: J Vis Exp, no. 99, pp. e52753, 2015, ISSN: 1940-087X (Electronic) 1940-087X (Linking).

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Ogielska, M.; Lanotte, P.; Le Brun, C.; Valentin, A. S.; Garot, D.; Tellier, A. C.; Halimi, J. M.; Colombat, P.; Guilleminault, L.; Lioger, B.; Vegas, H.; De Toffol, B.; Constans, T.; Bernard, L.

Emergence of community-acquired Clostridium difficile infection: the experience of a French hospital and review of the literature Journal Article

In: Int J Infect Dis, vol. 37, pp. 36-41, 2015, ISSN: 1878-3511 (Electronic) 1201-9712 (Linking).

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Galli, S. J.; Tsai, M.; Marichal, T.; Tchougounova, E.; Reber, L. L.; Pejler, G.

Approaches for analyzing the roles of mast cells and their proteases in vivo Journal Article

In: Adv Immunol, vol. 126, pp. 45-127, 2015, ISSN: 1557-8445 (Electronic) 0065-2776 (Linking).

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Gaillet, G.; Favelle, O.; Guilleminault, L.; de Muret, A.; Lemarie, E.; Lecomte, T.; Marchand-Adam, S.; Diot, P.

Gastroesophageal reflux disease is a risk factor for severity of organizing pneumonia Journal Article

In: Respiration, vol. 89, no. 2, pp. 119-26, 2015, ISSN: 1423-0356 (Electronic) 0025-7931 (Linking).

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Guilleminault, L.; Sigmann, M. H.; Paganin, F.

A good night for a bad day Journal Article

In: Thorax, vol. 70, no. 6, pp. 604, 607, 2015, ISSN: 1468-3296 (Electronic) 0040-6376 (Linking).

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Sedkaoui, K.; Leseux, L.; Pontier, S.; Rossin, N.; Leophonte, P.; Fraysse, J. L.; Didier, A.

Efficiency of a phone coaching program on adherence to continuous positive airway pressure in sleep apnea hypopnea syndrome: a randomized trial Journal Article

In: BMC Pulm Med, vol. 15, pp. 102, 2015, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Didier, A.; Malling, H. J.; Worm, M.; Horak, F.; Sussman, G. L.

Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score Journal Article

In: Clin Transl Allergy, vol. 5, pp. 12, 2015, ISSN: 2045-7022 (Print) 2045-7022 (Linking).

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Didier, A.; Campo, P.; Moreno, F.; Durand-Perdriel, F.; Marin, A.; Chartier, A.

Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with Allergic Rhinitis Journal Article

In: Int Arch Allergy Immunol, vol. 168, no. 3, pp. 182-92, 2015, ISSN: 1423-0097 (Electronic) 1018-2438 (Linking).

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Didier, A.; Bons, B.

Safety and tolerability of 5-grass pollen tablet sublingual immunotherapy: pooled analysis and clinical review Journal Article

In: Expert Opin Drug Saf, vol. 14, no. 5, pp. 777-88, 2015, ISSN: 1744-764X (Electronic) 1474-0338 (Linking).

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Pillard, F.; Lavit, M.; Cances, V. L.; Rami, J.; Houin, G.; Didier, A.; Riviere, D.

Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes Journal Article

In: Respir Res, vol. 16, pp. 155, 2015, ISSN: 1465-993X (Electronic) 1465-9921 (Linking).

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Roingeard, C.; Jaubert, J.; Guilleminault, L.

A large and unusual lung abscess with positive culture to Slackia exigua Journal Article

In: Int J Infect Dis, vol. 40, pp. 37-8, 2015, ISSN: 1878-3511 (Electronic) 1201-9712 (Linking).

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Marchand, S.; Bouchene, S.; de Monte, M.; Guilleminault, L.; Montharu, J.; Cabrera, M.; Gregoire, N.; Gobin, P.; Diot, P.; Couet, W.; Vecellio, L.

Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys Journal Article

In: Pharm Res, vol. 32, no. 10, pp. 3403-14, 2015, ISSN: 1573-904X (Electronic) 0724-8741 (Linking).

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Provost, D.; Iwatsubo, Y.; Riviere, S.; Mevel, M.; Didier, A.; Brochard, P.; Imbernon, E.; Raherison, C.

The impact of allergic rhinitis on the management of asthma in a working population Journal Article

In: BMC Pulm Med, vol. 15, pp. 142, 2015, ISSN: 1471-2466 (Electronic) 1471-2466 (Linking).

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Borgne, A. L.; Prevot, G.; Rouquette, I.; Huynh, A.; Tetu, L.; Projetti, F.; Carreiro, M.; Borie, R.; Jaccard, A.; Recher, C.; Didier, A.

Blood stem cell transplantation to treat cystic lung light chain deposition disease Journal Article

In: Eur Respir J, vol. 46, no. 4, pp. 1199-202, 2015, ISSN: 1399-3003 (Electronic) 0903-1936 (Linking).

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Guilleminault, L.; Carmier, D.; Heuze-Vourc'h, N.; Diot, P.; Pichon, E.

[Immunotherapy in non-small cell lung cancer: inhibition of PD1/PDL1 pathway] Journal Article

In: Rev Pneumol Clin, vol. 71, no. 1, pp. 44-56, 2015, ISSN: 0761-8417 (Print) 0761-8417 (Linking).

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Guibert, N.; Mazieres, J.; Marquette, C. H.; Rouviere, D.; Didier, A.; Hermant, C.

Integration of interventional bronchoscopy in the management of lung cancer Journal Article

In: Eur Respir Rev, vol. 24, no. 137, pp. 378-91, 2015, ISSN: 1600-0617 (Electronic) 0905-9180 (Linking).

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Collaborations

Kari Nadeau, MD, PhD, Université de Stanford, USA

Stephen J. Galli, MD, Université de Stanford, USA

Philipp Starkl, PhD, CeMM, Vienne, Autriche

Thomas Marichal, PhD, GIGA Institute, Liège, Belgique

Dr Nicolas Gaudenzio, UDEAR, Toulouse

Dr Pierre Bruhns Institut Pasteur, Paris

Hal Hoffman, MD, UC San Diego, USA

Dr. Vincent Serra, CSO NEOVACS, Paris

Impact on the society

Allergies are major public health problems of increasing prevalence and for which there is, in most cases, no efficient long-term therapy. Our team studies the cellular and molecular mechanisms of allergies, in order to identify potential new therapeutic targets. We develop and test new immunotherapeutic approaches to treat allergic diseases. To do so, we analyze clinical samples from allergic patients and use “humanized” mouse models of allergies, which allow us to directly assess the efficiencies of innovative therapies targeting key human proteins involved in allergic reactions. Our team is composed of scientists and clinicians, which allows us to perform both basic and translational research on allergies.

Partenaires Equipe L. REBER