Inflammatory diseases of the central nervous system: mechanisms and therapies

Coordinators : R. Liblau / A. Saoudi

Scientific Objectives


Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that usually begins in young adulthood and progressively leads to disability in most patients. Due to its increasing prevalence, its chronic course, and the partial effect of current disease-modifying drugs, MS has major socio-economical consequences. The overarching objective of our team is to decipher the pathophysiology of inflammatory diseases that target the CNS, with a particular focus on MS as well as other CNS autoimmune or infectious diseases.

Our Projects


AXE 1: T cells in autoimmune diseases of the CNS: migration, functions and regulation

Our aim is to better understand the cellular and molecular determinants leading to ageing and inflammation of the central nervous system (CNS).

To this end we have gathered unique experimental models as well as biological samples from patients. We wish to study the transmigration and effector functions of T cells, notably CD8 T cells, using several animal models of CNS inflammation that we have recently developed in the laboratory. More specifically:

1/ We study the immune mechanisms underlying type 1 narcolepsy, a chronic sleep disorder secondary to the loss of hypothalamic neurons secreting orexin/hypocretin. To this end, we study PBMCs and CSF from patients with type 1 narcolepsy, patients with other sleep disorders and healthy individuals. In addition, we have developed a unique mouse model of immune-mediated narcolepsy allowing us to study the mechanisms of hypothalamus tissue damage as well as the link between type 1 narcolepsy and the pandemic H1N1 influenza vaccine of 2009.

2/ Prof. Guillaume Martin-Blondel et Roland Liblau evaluate, using both in vivo mouse models and in vitro co-culture experiments, the bilateral interactions between T cells and BBB endothelial cells and their potential contribution to the development of inflammatory diseases of the CNS (ageing, multiple sclerosis, SUSAC syndrome, cerebral malaria,… ).

3/ In the frame of paraneoplastic neurological diseases we evaluate the mechanistic link between anti-tumor immune responses, cancer immunotherapy, and autoimmunity within the CNS.

4/ Using animal models of multiple sclerosis, we evaluate the possibility to reprogram regulatory T cells for therapeutic goals.

 

Coordinators: Prof Roland Liblau and Prof Guillaume Martin-Blondel
AXE 2: Role of environmental factors in regulating T cells in the context of MS

Multiple sclerosis (MS) is a leading cause of neurological disability affecting over 2.8 million individuals worldwide. There is currently no cure for MS as the etiology of the disease remains mostly unknown. MS is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that results from immune dysregulation, driven by a complex interplay between genetic predisposition and environmental factors. T cells play a key role in MS, with defective regulatory functions. T cell homeostasis is controlled by a series of proteins expressed on their surface that control their activation and differentiation, including the complement regulator CD46. Alteration of the CD46 pathway is described in a number of chronic inflammatory diseases, including MS, with dysfunctional induction of Tr1 cells, secreting IL-10.

Among environment factors linked to MS, Vitamin D deficiency is a growing public health problem proposed as a major risk factor, with an established correlation between low vitamin D levels and increased MS incidence and severity. However, the mechanisms involved are still mostly unknown.

Our group focuses on the mechanisms regulating human T cell activation and how environmental factors, such as Vitamin D deficiency, affect T cell activation and may contribute to pathogenesis. We also investigate how polymorphisms of genes associated with increased risk for MS contribute to this complex interaction.

Our main goals are to understand regulation of T cell differentiation and notably of Tr1 cells, and to determine the impact of vitamin D in T cells. We dissect the molecular mechanisms involved using primary human T cells from healthy donors and patients with MS. Our ultimate goal is to uncover novel pathways that could provide new immunotherapeutic targets for MS.

Coordinator: Dr Anne Astier
AXE 3: Role of T cell signaling molecules in central nervous system inflammation

 
Controlled T cell immunity is a prerequisite for health. An unbalanced response may lead to autoimmune diseases if the immune system reacts too strongly, or allow tumor expansion due to inadequate immune response. Hence, the control mechanisms for accurate T cell activation and differentiation are essential to maintain a good immune homeostasis. Signaling after the engagement of receptors expressed by T cells play an important role in controlling T cell functions and polymorphism or deficiency for these signaling genes could predispose to immune-mediated diseases.

In this regards, our recent studies revealed the implication of Vav1, Themis, CD46 and CD226 in T cell functions and susceptibility to immune mediated disorders. However, the cellular and molecular mechanisms by which these signaling molecules cooperate to regulate T cell function remain unknown.

The objectives of our project are therefore to:
AIM1: To investigate, using novel genetically engineered murine models, how Themis1 and Vav1 signaling molecules regulate T cell functions by dissecting the molecular mechanisms involved.
AIM2: To study how CD226 and CD46 contribute to aberrant response in patients with chronic inflammatory diseases such as multiple sclerosis.
AIM3: To analyze how environmental factors, or their deficiency such as ultraviolet radiation, affect T cell activation and may contribute to pathogenesis.

 

Coordinators: Dr Abdelhadi Saoudi and Dr Anne Astier
AXE4: Transcription factors in normal and pathological immune responses

 
Our group main interest is to dissect the cellular and molecular mechanisms whereby transcription factors drive immune responses in the central nervous sytem

We recently demonstrated that the transcription factor Foxo3 plays a key role in the physiopathology of CNS autoimmunity since Foxo3-deficiency is associated with a significant decrease in the severity of EAE. We also provided evidence that this decreased severity of EAE is the consequence of the inability of Foxo3-deficient CD4 T cells to differentiate into pathogenic T helper-1 (Th1) cells producing interferon- (IFN- and granulocyte monocyte colony stimulating factor (GM-CSF). At the molecular level, we showed that the Foxo3-Eomes axis is central to achieve the complete specialized gene program required for pathogenic Th1 cell differentiation and development of neuroinflammation.

In direct line with these data, our current project is to analyze the functions of the transcription factor Eomes in normal and pathological conditions and to evaluate the relevance of our results in humans by assessing the impact of a functional defect of FOXO3 and/or EOMES on T cell function from healthy donors or MS patients.

We also investigate the role of transcription factors in the management of neuronal death in neurodegenerative diseases. Indeed, we recently observed that Foxo3 deficient mice are resistant to the induction of neuronal death in a Parkinson’s disease model. We are now trying to elucidate the role of different cell types (neurons, microglia, CD4 T) deficient in Foxo3 in this neuroprotection, to characterize their translational and metabolic state, and interactions. We aim at proposing new therapeutics targeting both neuronal death and neuroinflammation in these multifactorial pathologies.

 

Coordinators: Dr Anne S. Dejean et Marion Szelechowski

Other information


Publications

2024

Kari, Saniya; Bucciarelli, Florence; Angles, Thibault; Oster, Anne-Cecile; Cauboue, Pauline; Laviolette, Karl; Mougenot, Madeline; Morandi, Elena; Bernard, Isabelle; Pignolet, Beatrice; Bost, Chloé; Thomas, Joelle; Nogueira, Leonor; Saoudi, Abdelhadi; Liblau, Roland; Astier, Anne L

Increased levels of circulating soluble CD226 in multiple sclerosis Journal Article

In: Mult Scler, pp. 13524585241234489, 2024, ISSN: 1477-0970.

Abstract | Links | BibTeX

2023

Liblau, Roland S; Latorre, Daniela; Kornum, Birgitte R; Dauvilliers, Yves; Mignot, Emmanuel J

The immunopathogenesis of narcolepsy type 1 Journal Article

In: Nat Rev Immunol, 2023, ISSN: 1474-1741.

Abstract | Links | BibTeX

Geeraerts, Thomas; Guilbeau-Frugier, Céline; Garcia, Cédric; Memier, Vincent; Raposo, Nicolas; Bonneville, Fabrice; Gales, Céline; Darcourt, Jean; Voisin, Sophie; Ribes, Agnès; Piel-Julian, Marie; Bounes, Fanny; Albucher, Jean François; Roux, Franck-Emmanuel; Izopet, Jacques; Telmon, Norbert; Olivot, Jean Marc; Sié, Pierre; Bauer, Jan; Payrastre, Bernard; Liblau, Roland S

Immunohistologic Features of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia Journal Article

In: Neurol Neuroimmunol Neuroinflamm, vol. 10, no. 4, 2023, ISSN: 2332-7812.

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Gonzalez-Fierro, Carmen; Fonte, Coralie; Dufourd, Eloïse; Cazaentre, Vincent; Aydin, Sidar; Engelhardt, Britta; Caspi, Rachel R; Xu, Biying; Martin-Blondel, Guillaume; Spicer, Julie A; Trapani, Joseph A; Bauer, Jan; Liblau, Roland S; Bost, Chloé

Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation Journal Article

In: Neurol Neuroimmunol Neuroinflamm, vol. 10, no. 4, 2023, ISSN: 2332-7812.

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Seifinejad, Ali; Ramosaj, Mergim; Shan, Ling; Li, Sha; Possovre, Marie-Laure; Pfister, Corinne; Fronczek, Rolf; Garrett-Sinha, Lee A; Frieser, David; Honda, Makoto; Arribat, Yoan; Grepper, Dogan; Amati, Francesca; Picot, Marie; Agnoletto, Andrea; Iseli, Christian; Chartrel, Nicolas; Liblau, Roland; Lammers, Gert J; Vassalli, Anne; Tafti, Mehdi

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy Journal Article

In: Proc Natl Acad Sci U S A, vol. 120, no. 19, pp. e2220911120, 2023, ISSN: 1091-6490.

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Aydin, Sidar; Pareja, Javier; Schallenberg, Vivianne M; Klopstein, Armelle; Gruber, Thomas; Page, Nicolas; Bouillet, Elisa; Blanchard, Nicolas; Liblau, Roland; Körbelin, Jakob; Schwaninger, Markus; Johnson, Aaron J; Schenk, Mirjam; Deutsch, Urban; Merkler, Doron; Engelhardt, Britta

Antigen recognition detains CD8 T cells at the blood-brain barrier and contributes to its breakdown Journal Article

In: Nat Commun, vol. 14, no. 1, pp. 3106, 2023, ISSN: 2041-1723.

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Martin-Blondel, Guillaume; Marcelin, Anne-Geneviève; Soulié, Cathia; Kaisaridi, Sofia; Lusivika-Nzinga, Clovis; Zafilaza, Karen; Dorival, Céline; Nailler, Laura; Boston, Anaïs; Ronchetti, Anne-Marie; Melenotte, Cléa; Cabié, André; Choquet, Christophe; Trinh-Duc, Albert; Lacombe, Karine; Gaube, Géraldine; Coustillères, François; Pourcher, Valérie; Martellosio, Jean-Philippe; Peiffer-Smadja, Nathan; Chauveau, Marie; Housset, Pierre; Piroth, Lionel; Devaux, Mathilde; Pialoux, Gilles; Martin, Aurélie; Dubee, Vincent; Frey, Jérôme; Bot, Audrey Le; Cazanave, Charles; Petua, Philippe; Liblau, Roland; Carrat, Fabrice; Yordanov, Youri

Time to negative PCR conversion amongst high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated with sotrovimab or nirmatrelvir Journal Article

In: Clin Microbiol Infect, vol. 29, no. 4, pp. 543.e5–543.e9, 2023, ISSN: 1469-0691.

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Texier, Baptiste; Prime, Morgane; Atamena, Djamaa; Belenguer, Pascale; Szelechowski, Marion

Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson's disease Journal Article

In: Neural Regen Res, vol. 18, no. 2, pp. 293–298, 2023, ISSN: 1673-5374.

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Faure, Fabrice; Yshii, Lidia; Renno, Toufic; Coste, Isabelle; Joubert, Bastien; Desestret, Virginie; Liblau, Roland; Honnorat, Jérôme

A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model Journal Article

In: Cerebellum, 2023, ISSN: 1473-4230.

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Astier, Anne L; Kofler, David M

Editorial: Dysregulation of Th17 and Treg cells in autoimmune diseases Journal Article

In: Front Immunol, vol. 14, pp. 1151836, 2023, ISSN: 1664-3224.

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Ayoub, Ikram; Dauvilliers, Yves; Barateau, Lucie; Vermeulen, Thaïs; Mouton-Barbosa, Emmanuelle; Marcellin, Marlène; Gonzalez-de-Peredo, Anne; Gross, Catharina C; Saoudi, Abdelhadi; Liblau, Roland

Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system Journal Article

In: Front Immunol, vol. 14, pp. 1108682, 2023, ISSN: 1664-3224.

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de Sèze, Jérôme; Maillart, Elisabeth; Gueguen, Antoine; Laplaud, David A; Michel, Laure; Thouvenot, Eric; Zephir, Hélène; Zimmer, Luc; Biotti, Damien; Liblau, Roland

Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic Journal Article

In: Front Immunol, vol. 14, pp. 1004795, 2023, ISSN: 1664-3224.

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2022

Schneider-Hohendorf, Tilman; Gerdes, Lisa Ann; Pignolet, Béatrice; Gittelman, Rachel; Ostkamp, Patrick; Rubelt, Florian; Raposo, Catarina; Tackenberg, Björn; Riepenhausen, Marianne; Janoschka, Claudia; Wünsch, Christian; Bucciarelli, Florence; Flierl-Hecht, Andrea; Beltrán, Eduardo; Kümpfel, Tania; Anslinger, Katja; Gross, Catharina C; Chapman, Heidi; Kaplan, Ian; Brassat, David; Wekerle, Hartmut; Kerschensteiner, Martin; Klotz, Luisa; Lünemann, Jan D; Hohlfeld, Reinhard; Liblau, Roland; Wiendl, Heinz; Schwab, Nicholas

Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis Journal Article

In: J Exp Med, vol. 219, no. 11, 2022, ISSN: 1540-9538.

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Martin-Blondel, Guillaume; Marcelin, Anne-Genevieve; Soulié, Cathia; Kaisaridi, Sofia; Lusivika-Nzinga, Clovis; Dorival, Céline; Nailler, Laura; Boston, Anaïs; Melenotte, Cléa; Cabié, André; Choquet, Christophe; Coustillères, François; Martellosio, Jean-Philippe; Gaube, Géraldine; Trinh-Duc, Albert; Ronchetti, Anne-Marie; Pourcher, Valerie; Chauveau, Marie; Lacombe, Karine; Peiffer-Smadja, Nathan; Housset, Pierre; Perrot, Aurore; Pialoux, Gilles; Martin, Aurélie; Dubee, Vincent; Devaux, Mathilde; Frey, Jérôme; Cazanave, Charles; Liblau, Roland; Carrat, Fabrice; Yordanov, Youri

Sotrovimab to prevent severe COVID-19 in high-risk patients infected with Omicron BA.2 Miscellaneous

2022, ISSN: 1532-2742.

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Chiu, Isaac M; Liblau, Roland

Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease Miscellaneous

2022, ISSN: 1879-0372.

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Merkler, Doron; Vincenti, Ilena; Masson, Frederick; Liblau, Roland S

Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty Journal Article

In: Curr Opin Immunol, vol. 77, pp. 102211, 2022, ISSN: 1879-0372.

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Bernard-Valnet, Raphaël; Frieser, David; Nguyen, Xuan Hung; Khajavi, Leila; Quériault, Clémence; Arthaud, Sébastien; Melzi, Silvia; Fusade-Boyer, Maxime; Masson, Frederick; Zytnicki, Matthias; Saoudi, Abdelhadi; Dauvilliers, Yves; Peyron, Christelle; Bauer, Jan; Liblau, Roland S

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy Journal Article

In: Brain, vol. 145, no. 6, pp. 2018–2030, 2022, ISSN: 1460-2156.

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Bernard-Valnet, Raphaël; Frieser, David; Nguyen, Xuan Hung; Khajavi, Leila; Quériault, Clémence; Arthaud, Sébastien; Melzi, Silvia; Fusade-Boyer, Maxime; Masson, Frederick; Zytnicki, Matthias; Saoudi, Abdelhadi; Dauvilliers, Yves; Peyron, Christelle; Bauer, Jan; Liblau, Roland S

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy Journal Article

In: Brain, vol. 145, no. 6, pp. 2018–2030, 2022, ISSN: 1460-2156.

Abstract | Links | BibTeX

Gaudenzio, Nicolas; Liblau, Roland S

Immune cells impede repair of old neurons Journal Article

In: Science, vol. 376, no. 6594, pp. 694–695, 2022, ISSN: 1095-9203.

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Frieser, David; Pignata, Aurora; Khajavi, Leila; Shlesinger, Danielle; Gonzalez-Fierro, Carmen; Nguyen, Xuan-Hung; Yermanos, Alexander; Merkler, Doron; Höftberger, Romana; Desestret, Virginie; Mair, Katharina M; Bauer, Jan; Masson, Frederick; Liblau, Roland S

Tissue-resident CD8 T cells drive compartmentalized and chronic autoimmune damage against CNS neurons Journal Article

In: Sci Transl Med, vol. 14, no. 640, pp. eabl6157, 2022, ISSN: 1946-6242.

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Hohlfeld, Reinhard; Liblau, Roland S

Toward identification of personalized immunological profiles in multiple sclerosis Journal Article

In: Sci Adv, vol. 8, no. 17, pp. eabq4849, 2022, ISSN: 2375-2548.

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Kreutmair, Stefanie; Unger, Susanne; Núñez, Nicolás Gonzalo; Ingelfinger, Florian; Alberti, Chiara; Feo, Donatella De; Krishnarajah, Sinduya; Kauffmann, Manuel; Friebel, Ekaterina; Babaei, Sepideh; Gaborit, Benjamin; Lutz, Mirjam; Jurado, Nicole Puertas; Malek, Nisar P; Goepel, Siri; Rosenberger, Peter; Häberle, Helene A; Ayoub, Ikram; Al-Hajj, Sally; Nilsson, Jakob; Claassen, Manfred; Liblau, Roland; Martin-Blondel, Guillaume; Bitzer, Michael; Roquilly, Antoine; Becher, Burkhard

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia Miscellaneous

2022, ISSN: 1097-4180.

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Galoppin, Manon; Kari, Saniya; Soldati, Sasha; Pal, Arindam; Rival, Manon; Engelhardt, Britta; Astier, Anne; Thouvenot, Eric

Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications Journal Article

In: Brain Commun, vol. 4, no. 4, pp. fcac171, 2022, ISSN: 2632-1297.

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Yang, Cui; Blaize, Gaëtan; Marrocco, Rémi; Rouquié, Nelly; Bories, Cyrielle; Gador, Mylène; Mélique, Suzanne; Joulia, Emeline; Benamar, Mehdi; Dejean, Anne S.; Daniels-Treffandier, Hélène; Love, Paul E.; Fazilleau, Nicolas; Saoudi, Abdelhadi; Lesourne, Renaud

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals Journal Article

In: Science Signaling, vol. 15, no. 742, pp. eabl5343, 2022, (Publisher: American Association for the Advancement of Science).

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2021

Tuzlak, Selma; Dejean, Anne S; Iannacone, Matteo; Quintana, Francisco J; Waisman, Ari; Ginhoux, Florent; Korn, Thomas; Becher, Burkhard

Repositioning T cell polarization from single cytokines to complex help Journal Article

In: Nat Immunol, vol. 22, no. 10, pp. 1210–1217, 2021, ISSN: 1529-2916.

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Wiendl, Heinz; Gross, Catharina C; Bauer, Jan; Merkler, Doron; Prat, Alexandre; Liblau, Roland

Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases Journal Article

In: Nat Rev Neurol, vol. 17, no. 7, pp. 433–447, 2021, ISSN: 1759-4766.

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Karmakar, Utsa; Chu, Julia Y; Sundaram, Kruthika; Astier, Anne L; Garside, Hannah; Hansen, Carsten G; Dransfield, Ian; Vermeren, Sonja

Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions Journal Article

In: Cell Death Dis, vol. 12, no. 4, pp. 296, 2021, ISSN: 2041-4889.

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Rousset, S.; Lafaurie, M.; Guet-Revillet, H.; Protin, C.; Le Grusse, J.; Derumeaux, H.; Gandia, P.; Nourhashemi, F.; Sailler, L.; Sommet, A.; Delobel, P.; Martin-Blondel, G.

Safety of Pyrazinamide for the Treatment of Tuberculosis in Older Patients Over 75 Years of Age: A Retrospective Monocentric Cohort Study Journal Article

In: Drugs Aging, vol. 38, no. 1, pp. 43-52, 2021, ISSN: 1179-1969 (Electronic) 1170-229X (Linking).

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Guyonnet, S; Rolland, Y; Takeda, C; Ousset, P-J; Ader, I; Davezac, N; Dray, C; Fazilleau, N; Gourdy, P; Liblau, R; Parini, A; Payoux, P; Pénicaud, L; Rampon, C; Valet, P; Vergnolle, N; Andrieu, S; de Souto Barreto, P; Casteilla, L; Vellas, B

The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort) Journal Article

In: J Frailty Aging, vol. 10, no. 2, pp. 110–120, 2021, ISSN: 2260-1341.

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de Souto Barreto, P; Guyonnet, S; Ader, I; Andrieu, S; Casteilla, L; Davezac, N; Dray, C; Fazilleau, N; Gourdy, P; Liblau, R; Parini, A; Payoux, P; Pénicaud, L; Rampon, C; Rolland, Y; Valet, P; Vergnolle, N; Vellas, B

The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System Journal Article

In: J Frailty Aging, vol. 10, no. 2, pp. 86–93, 2021, ISSN: 2260-1341.

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2020

Cohen, M.; Mondot, L.; Bucciarelli, F.; Pignolet, B.; Laplaud, D. A.; Wiertlewski, S.; Brochet, B.; Ruet, A.; Defer, G.; Derache, N.; Vermersch, P.; Zephir, H.; Debouverie, M.; Mathey, G.; Berger, E.; Cappe, C.; Labauge, P.; Carra, C.; De Seze, J.; Bigaut, K.; Brassat, D.; Lebrun-Frenay, C.

BEST-MS: A prospective head-to-head comparative study of natalizumab and fingolimod in active relapsing MS Journal Article

In: Mult Scler, pp. 1352458520969145, 2020, ISSN: 1477-0970 (Electronic) 1352-4585 (Linking).

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Yshii, L.; Bost, C.; Liblau, R.

Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications Journal Article

In: Front Immunol, vol. 11, pp. 991, 2020, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

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Pavlovic, M.; Gross, C.; Chili, C.; Secher, T.; Treiner, E.

MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands Journal Article

In: Front Immunol, vol. 11, pp. 2097, 2020, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

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Malviya, M.; Saoudi, A.; Bauer, J.; Fillatreau, S.; Liblau, R.

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells Journal Article

In: J Autoimmun, vol. 108, pp. 102401, 2020, ISSN: 1095-9157 (Electronic) 0896-8411 (Linking).

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Killick, J.; Hay, J.; Morandi, E.; Vermeren, S.; Kari, S.; Angles, T.; Williams, A.; Damoiseaux, J.; Astier, A. L.

Vitamin D/CD46 Crosstalk in Human T Cells in Multiple Sclerosis Journal Article

In: Front Immunol, vol. 11, pp. 598727, 2020, ISSN: 1664-3224 (Electronic) 1664-3224 (Linking).

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Kamar, N.; Esposito, L.; Hebral, A. L.; Guitard, J.; Del Bello, A.

Specific organization for in-hospital belatacept infusion to avoid nosocomial transmission during the SARS-CoV-2 pandemic Journal Article

In: Am J Transplant, vol. 20, no. 10, pp. 2962-2963, 2020, ISSN: 1600-6143 (Electronic) 1600-6135 (Linking).

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Del Bello, A.; Kamar, N.; Treiner, E.

T cell reconstitution after lymphocyte depletion features a different pattern of inhibitory receptor expression in ABO- versus HLA-incompatible kidney transplant recipients Journal Article

In: Clin Exp Immunol, vol. 200, no. 1, pp. 89-104, 2020, ISSN: 1365-2249 (Electronic) 0009-9104 (Linking).

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2019

Eyoh, Enwono; McCallum, Patrick; Killick, Justin; Amanfo, Seth; Mutapi, Francisca; Astier, Anne L

The anthelmintic drug praziquantel promotes human Tr1 differentiation Journal Article

In: Immunol Cell Biol, vol. 97, no. 5, pp. 512–518, 2019, ISSN: 1440-1711.

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Giner-Delgado, C.; Villatoro, S.; Lerga-Jaso, J.; Gaya-Vidal, M.; Oliva, M.; Castellano, D.; Pantano, L.; Bitarello, B. D.; Izquierdo, D.; Noguera, I.; Olalde, I.; Delprat, A.; Blancher, A.; Lalueza-Fox, C.; Esko, T.; O'Reilly, P. F.; Andres, A. M.; Ferretti, L.; Puig, M.; Caceres, M.

Evolutionary and functional impact of common polymorphic inversions in the human genome Journal Article

In: Nat Commun, vol. 10, no. 1, pp. 4222, 2019, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Dejean, A. S.; Joulia, E.; Walzer, T.

The role of Eomes in human CD4 T cell differentiation: A question of context Journal Article

In: Eur J Immunol, vol. 49, no. 1, pp. 38-41, 2019, ISSN: 1521-4141 (Electronic) 0014-2980 (Linking).

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Beltran, E.; Nguyen, X. H.; Queriault, C.; Barateau, L.; Dauvilliers, Y.; Dornmair, K.; Liblau, R. S.

Shared T cell receptor chains in blood memory CD4(+) T cells of narcolepsy type 1 patients Journal Article

In: J Autoimmun, vol. 100, pp. 1-6, 2019, ISSN: 1095-9157 (Electronic) 0896-8411 (Linking).

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Bassetti, C. L. A.; Adamantidis, A.; Burdakov, D.; Han, F.; Gay, S.; Kallweit, U.; Khatami, R.; Koning, F.; Kornum, B. R.; Lammers, G. J.; Liblau, R. S.; Luppi, P. H.; Mayer, G.; Pollmacher, T.; Sakurai, T.; Sallusto, F.; Scammell, T. E.; Tafti, M.; Dauvilliers, Y.

Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment Journal Article

In: Nat Rev Neurol, vol. 15, no. 9, pp. 519-539, 2019, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

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Aron Badin, R.; Bugi, A.; Williams, S.; Vadori, M.; Michael, M.; Jan, C.; Nassi, A.; Lecourtois, S.; Blancher, A.; Cozzi, E.; Hantraye, P.; Perrier, A. L.

MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates Journal Article

In: Nat Commun, vol. 10, no. 1, pp. 4357, 2019, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Yshii, L.; Pignolet, B.; Maure, E.; Pierau, M.; Brunner-Weinzierl, M.; Hartley, O.; Bauer, J.; Liblau, R.

IFN-gamma is a therapeutic target in paraneoplastic cerebellar degeneration Journal Article

In: JCI Insight, vol. 4, no. 7, 2019, ISSN: 2379-3708 (Electronic) 2379-3708 (Linking).

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Klotz, L.; Eschborn, M.; Lindner, M.; Liebmann, M.; Herold, M.; Janoschka, C.; Torres Garrido, B.; Schulte-Mecklenbeck, A.; Gross, C. C.; Breuer, J.; Hundehege, P.; Posevitz, V.; Pignolet, B.; Nebel, G.; Glander, S.; Freise, N.; Austermann, J.; Wirth, T.; Campbell, G. R.; Schneider-Hohendorf, T.; Eveslage, M.; Brassat, D.; Schwab, N.; Loser, K.; Roth, J.; Busch, K. B.; Stoll, M.; Mahad, D. J.; Meuth, S. G.; Turner, T.; Bar-Or, A.; Wiendl, H.

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects Journal Article

In: Sci Transl Med, vol. 11, no. 490, 2019, ISSN: 1946-6242 (Electronic) 1946-6234 (Linking).

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Walter, O.; Treiner, E.; Bonneville, F.; Mengelle, C.; Vergez, F.; Lerebours, F.; Delobel, P.; Liblau, R.; Martin-Blondel, G.; Immune Checkpoint Inhibitors in, P. M. L. Study Group

Treatment of Progressive Multifocal Leukoencephalopathy with Nivolumab Journal Article

In: N Engl J Med, vol. 380, no. 17, pp. 1674-1676, 2019, ISSN: 1533-4406 (Electronic) 0028-4793 (Linking).

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Rousset, S.; Treiner, E.; Moulis, G.; Pugnet, G.; Astudillo, L.; Paricaud, K.; Puissant-Lubrano, B.; Arlet, P.; Blancher, A.; Sailler, L.

High rate of indeterminate results of the QuantiFERON-TB Gold in-tube test, third generation, in patients with systemic vasculitis Journal Article

In: Rheumatology (Oxford), 2019, ISSN: 1462-0332 (Electronic) 1462-0324 (Linking).

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Salvioni, A.; Belloy, M.; Lebourg, A.; Bassot, E.; Cantaloube-Ferrieu, V.; Vasseur, V.; Blanie, S.; Liblau, R. S.; Suberbielle, E.; Robey, E. A.; Blanchard, N.

Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons Journal Article

In: Cell Rep, vol. 27, no. 11, pp. 3254-3268 e8, 2019, ISSN: 2211-1247 (Electronic).

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Schwab, N.; Schneider-Hohendorf, T.; Pignolet, B.; Bucciarelli, F.; Scandella, L.; Ciron, J.; Biotti, D.; Lebrun-Frenay, C.; Mathey, G.; Clavelou, P.; Pelletier, J.; Ostkamp, P.; Meinl, I.; Windhagen, S.; Klotz, L.; Gross, C. C.; Meuth, S. G.; Deisenhammer, F.; Brassat, D.; Wiendl, H.; Best, M. S. Study Group

Prospective validation of the PML risk biomarker l-selectin and influence of natalizumab extended intervals Journal Article

In: Neurology, vol. 93, no. 12, pp. 550-554, 2019, ISSN: 1526-632X (Electronic) 0028-3878 (Linking).

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2018

Montalban, X.; Gold, R.; Thompson, A. J.; Otero-Romero, S.; Amato, M. P.; Chandraratna, D.; Clanet, M.; Comi, G.; Derfuss, T.; Fazekas, F.; Hartung, H. P.; Havrdova, E.; Hemmer, B.; Kappos, L.; Liblau, R.; Lubetzki, C.; Marcus, E.; Miller, D. H.; Olsson, T.; Pilling, S.; Selmaj, K.; Siva, A.; Sorensen, P. S.; Sormani, M. P.; Thalheim, C.; Wiendl, H.; Zipp, F.

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis Journal Article

In: Mult Scler, vol. 24, no. 2, pp. 96-120, 2018, ISSN: 1477-0970 (Electronic) 1352-4585 (Linking).

Links | BibTeX

Januel, E.; Martin-Blondel, G.; Lamirel, C.; Picard, H.; Pialoux, G.; Katlama, C.; Cochereau, I.; Lescure, F. X.; Moulignier, A.

Do CCR5 antagonists improve the overall survival of patients with AIDS-related progressive multifocal leucoencephalopathy? Journal Article

In: J Neurol Neurosurg Psychiatry, vol. 89, no. 10, pp. 1125-1126, 2018, ISSN: 1468-330X (Electronic) 0022-3050 (Linking).

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Mansuy, J. M.; Lhomme, S.; Cazabat, M.; Pasquier, C.; Martin-Blondel, G.; Izopet, J.

Detection of Zika, dengue and chikungunya viruses using single-reaction multiplex real-time RT-PCR Journal Article

In: Diagn Microbiol Infect Dis, vol. 92, no. 4, pp. 284-287, 2018, ISSN: 1879-0070 (Electronic) 0732-8893 (Linking).

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Melliez, H.; Mary-Krause, M.; Bocket, L.; Guiguet, M.; Abgrall, S.; De Truchis, P.; Katlama, C.; Martin-Blondel, G.; Henn, A.; Revest, M.; Robineau, O.; Khuong-Josses, M. A.; Canestri, A.; De Castro, N.; Joly, V.; Mokhtari, S.; Risso, K.; Gasnault, J.; Costagliola, D.; French Hospital Database on, H. I. V.

Risk of Progressive Multifocal Leukoencephalopathy in the Combination Antiretroviral Therapy Era in the French Hospital Database on Human Immunodeficiency Virus (ANRS-C4) Journal Article

In: Clin Infect Dis, vol. 67, no. 2, pp. 275-282, 2018, ISSN: 1537-6591 (Electronic) 1058-4838 (Linking).

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Gaud, G.; Roncagalli, R.; Chaoui, K.; Bernard, I.; Familiades, J.; Colacios, C.; Kassem, S.; Monsarrat, B.; Burlet-Schiltz, O.; de Peredo, A. G.; Malissen, B.; Saoudi, A.

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4(+) T cells Journal Article

In: Sci Signal, vol. 11, no. 538, 2018, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

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Tugues, S.; Amorim, A.; Spath, S.; Martin-Blondel, G.; Schreiner, B.; De Feo, D.; Lutz, M.; Guscetti, F.; Apostolova, P.; Haftmann, C.; Hasselblatt, P.; Nunez, N. G.; Hottiger, M. O.; van den Broek, M.; Manz, M. G.; Zeiser, R.; Becher, B.

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells Journal Article

In: Sci Transl Med, vol. 10, no. 469, 2018, ISSN: 1946-6242 (Electronic) 1946-6234 (Linking).

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Liblau, R. S.

Put to sleep by immune cells Journal Article

In: Nature, vol. 562, no. 7725, pp. 46-48, 2018, ISSN: 1476-4687 (Electronic) 0028-0836 (Linking).

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Eissmann, M. F.; Dijkstra, C.; Wouters, M. A.; Baloyan, D.; Mouradov, D.; Nguyen, P. M.; Davalos-Salas, M.; Putoczki, T. L.; Sieber, O. M.; Mariadason, J. M.; Ernst, M.; Masson, F.

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-gamma-Dependent Manner Journal Article

In: Cancer Immunol Res, vol. 6, no. 4, pp. 409-421, 2018, ISSN: 2326-6074 (Electronic) 2326-6066 (Linking).

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2017

Gebauer, C.; Pignolet, B.; Yshii, L.; Maure, E.; Bauer, J.; Liblau, R.

CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model Journal Article

In: Oncoimmunology, vol. 6, no. 2, pp. e1260212, 2017, ISSN: 2162-4011 (Print) 2162-4011 (Linking).

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Fissolo, N.; Pignolet, B.; Matute-Blanch, C.; Trivino, J. C.; Miro, B.; Mota, M.; Perez-Hoyos, S.; Sanchez, A.; Vermersch, P.; Ruet, A.; de Seze, J.; Labauge, P.; Vukusic, S.; Papeix, C.; Almoyna, L.; Tourbah, A.; Clavelou, P.; Moreau, T.; Pelletier, J.; Lebrun-Frenay, C.; Montalban, X.; Brassat, D.; Comabella, M.; Biomarkers,; Response to Natalizumab for Multiple Sclerosis Treatment, Best EScalation Treatment in Multiple Sclerosis; the Societe Francophone de la Sclerose En Plaques, Network

Matrix metalloproteinase 9 is decreased in natalizumab-treated multiple sclerosis patients at risk for progressive multifocal leukoencephalopathy Journal Article

In: Ann Neurol, vol. 82, no. 2, pp. 186-195, 2017, ISSN: 1531-8249 (Electronic) 0364-5134 (Linking).

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Ni Choileain, S.; Hay, J.; Thomas, J.; Williams, A.; Vermeren, M. M.; Benezech, C.; Gomez-Salazar, M.; Hugues, O. R.; Vermeren, S.; Howie, S. E. M.; Dransfield, I.; Astier, A. L.

TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells Journal Article

In: Sci Signal, vol. 10, no. 502, 2017, ISSN: 1937-9145 (Electronic) 1945-0877 (Linking).

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Yshii, L. M.; Hohlfeld, R.; Liblau, R. S.

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives Journal Article

In: Nat Rev Neurol, vol. 13, no. 12, pp. 755-763, 2017, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

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Yu, C.; Fitzpatrick, A.; Cong, D.; Yao, C.; Yoo, J.; Turnbull, A.; Schwarze, J.; Norval, M.; Howie, S. E. M.; Weller, R. B.; Astier, A. L.

Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential Journal Article

In: J Allergy Clin Immunol, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

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Duguet, F.; Locard-Paulet, M.; Marcellin, M.; Chaoui, K.; Bernard, I.; Andreoletti, O.; Lesourne, R.; Burlet-Schiltz, O.; Gonzalez de Peredo, A.; Saoudi, A.

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function Journal Article

In: Mol Cell Proteomics, vol. 16, no. 8, pp. 1416-1432, 2017, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

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Yu, C.; Fitzpatrick, A.; Cong, D.; Yao, C.; Yoo, J.; Turnbull, A.; Schwarze, J.; Norval, M.; Howie, S. E. M.; Weller, R. B.; Astier, A. L.

Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential Journal Article

In: J Allergy Clin Immunol, 2017, ISSN: 1097-6825 (Electronic) 0091-6749 (Linking).

Links | BibTeX

Yshii, L. M.; Hohlfeld, R.; Liblau, R. S.

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives Journal Article

In: Nat Rev Neurol, vol. 13, no. 12, pp. 755-763, 2017, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

Links | BibTeX

2016

Schwab, N.; Schneider-Hohendorf, T.; Pignolet, B.; Spadaro, M.; Gorlich, D.; Meinl, I.; Windhagen, S.; Tackenberg, B.; Breuer, J.; Canto, E.; Kumpfel, T.; Hohlfeld, R.; Siffrin, V.; Luessi, F.; Posevitz-Fejfar, A.; Montalban, X.; Meuth, S. G.; Zipp, F.; Gold, R.; Du Pasquier, R. A.; Kleinschnitz, C.; Jacobi, A.; Comabella, M.; Bertolotto, A.; Brassat, D.; Wiendl, H.

PML risk stratification using anti-JCV antibody index and L-selectin Journal Article

In: Mult Scler, vol. 22, no. 8, pp. 1048-60, 2016, ISSN: 1477-0970 (Electronic) 1352-4585 (Linking).

Links | BibTeX

Pignolet, B.; Schwab, N.; Schneider-Hohendorf, T.; Bucciarelli, F.; Biotti, D.; Averseng-Peaureaux, D.; Outteryck, O.; Ongagna, J. C.; de Seze, J.; Brochet, B.; Ouallet, J. C.; Debouverie, M.; Pittion, S.; Defer, G.; Derache, N.; Hautecoeur, P.; Tourbah, A.; Labauge, P.; Castelnovo, G.; Clavelou, P.; Berger, E.; Pelletier, J.; Rico, A.; Zephir, H.; Laplaud, D.; Wiertlewski, S.; Camu, W.; Thouvenot, E.; Casez, O.; Moreau, T.; Fromont, A.; Vukusic, S.; Papeix, C.; Vermersch, P.; Comabella, M.; Lebrun-Frenay, C.; Wiendl, H.; Brassat, D.; Bionat, Sfsep; networks, Best-Ms

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy Journal Article

In: Neurology, vol. 87, no. 23, pp. 2491-2494, 2016, ISSN: 1526-632X (Electronic) 0028-3878 (Linking).

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Yshii, L. M.; Gebauer, C. M.; Pignolet, B.; Maure, E.; Queriault, C.; Pierau, M.; Saito, H.; Suzuki, N.; Brunner-Weinzierl, M.; Bauer, J.; Liblau, R.

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model Journal Article

In: Brain, 2016, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

Links | BibTeX

Martin-Blondel, G.; Brassat, D.; Bauer, J.; Lassmann, H.; Liblau, R. S.

CCR5 blockade for neuroinflammatory diseases--beyond control of HIV Journal Article

In: Nat Rev Neurol, vol. 12, no. 2, pp. 95-105, 2016, ISSN: 1759-4766 (Electronic) 1759-4758 (Linking).

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Kassem, S.; Gaud, G.; Bernard, I.; Benamar, M.; Dejean, A. S.; Liblau, R.; Fournie, G. J.; Colacios, C.; Malissen, B.; Saoudi, A.

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation Journal Article

In: PLoS Genet, vol. 12, no. 7, pp. e1006185, 2016, ISSN: 1553-7404 (Electronic) 1553-7390 (Linking).

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Stienne, C.; Michieletto, M. F.; Benamar, M.; Carrie, N.; Bernard, I.; Nguyen, X. H.; Lippi, Y.; Duguet, F.; Liblau, R. S.; Hedrick, S. M.; Saoudi, A.; Dejean, A. S.

Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes Journal Article

In: Immunity, vol. 45, no. 4, pp. 774-787, 2016, ISSN: 1097-4180 (Electronic) 1074-7613 (Linking).

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Mansuy, J. M.; Suberbielle, E.; Chapuy-Regaud, S.; Mengelle, C.; Bujan, L.; Marchou, B.; Delobel, P.; Gonzalez-Dunia, D.; Malnou, C. E.; Izopet, J.; Martin-Blondel, G.

Zika virus in semen and spermatozoa Journal Article

In: Lancet Infect Dis, vol. 16, no. 10, pp. 1106-1107, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Mansuy, J. M.; Dutertre, M.; Mengelle, C.; Fourcade, C.; Marchou, B.; Delobel, P.; Izopet, J.; Martin-Blondel, G.

Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Journal Article

In: Lancet Infect Dis, vol. 16, no. 4, pp. 405, 2016, ISSN: 1474-4457 (Electronic) 1473-3099 (Linking).

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Hartmann, F. J.; Bernard-Valnet, R.; Queriault, C.; Mrdjen, D.; Weber, L. M.; Galli, E.; Krieg, C.; Robinson, M. D.; Nguyen, X. H.; Dauvilliers, Y.; Liblau, R. S.; Becher, B.

High-dimensional single-cell analysis reveals the immune signature of narcolepsy Journal Article

In: J Exp Med, vol. 213, no. 12, pp. 2621-2633, 2016, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

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Ramadan, A.; Lucca, L. E.; Carrie, N.; Desbois, S.; Axisa, P. P.; Hayder, M.; Bauer, J.; Liblau, R. S.; Mars, L. T.

In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS Journal Article

In: Brain, vol. 139, no. Pt 5, pp. 1433-46, 2016, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

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Kieback, E.; Hilgenberg, E.; Stervbo, U.; Lampropoulou, V.; Shen, P.; Bunse, M.; Jaimes, Y.; Boudinot, P.; Radbruch, A.; Klemm, U.; Kuhl, A. A.; Liblau, R.; Hoevelmeyer, N.; Anderton, S. M.; Uckert, W.; Fillatreau, S.

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity Journal Article

In: Immunity, vol. 44, no. 5, pp. 1114-26, 2016, ISSN: 1097-4180 (Electronic) 1074-7613 (Linking).

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Hartmann, F. J.; Bernard-Valnet, R.; Queriault, C.; Mrdjen, D.; Weber, L. M.; Galli, E.; Krieg, C.; Robinson, M. D.; Nguyen, X. H.; Dauvilliers, Y.; Liblau, R. S.; Becher, B.

High-dimensional single-cell analysis reveals the immune signature of narcolepsy Journal Article

In: J Exp Med, vol. 213, no. 12, pp. 2621-2633, 2016, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

Links | BibTeX

Yshii, L. M.; Gebauer, C. M.; Pignolet, B.; Maure, E.; Queriault, C.; Pierau, M.; Saito, H.; Suzuki, N.; Brunner-Weinzierl, M.; Bauer, J.; Liblau, R.

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model Journal Article

In: Brain, 2016, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

Links | BibTeX

Aloulou, M.; Carr, E. J.; Gador, M.; Bignon, A.; Liblau, R. S.; Fazilleau, N.; Linterman, M. A.

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells Journal Article

In: Nat Commun, vol. 7, pp. 10579, 2016, ISSN: 2041-1723 (Electronic) 2041-1723 (Linking).

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Bernard-Valnet, R.; Yshii, L.; Queriault, C.; Nguyen, X. H.; Arthaud, S.; Rodrigues, M.; Canivet, A.; Morel, A. L.; Matthys, A.; Bauer, J.; Pignolet, B.; Dauvilliers, Y.; Peyron, C.; Liblau, R. S.

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice Journal Article

In: Proc Natl Acad Sci U S A, vol. 113, no. 39, pp. 10956-61, 2016, ISSN: 1091-6490 (Electronic) 0027-8424 (Linking).

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2015

Martin-Blondel, G.; Bauer, J.; Uro-Coste, E.; Biotti, D.; Averseng-Peaureaux, D.; Fabre, N.; Dumas, H.; Bonneville, F.; Lassmann, H.; Marchou, B.; Liblau, R. S.; Brassat, D.

Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8(+) T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome Journal Article

In: Acta Neuropathol, vol. 129, no. 3, pp. 463-5, 2015, ISSN: 1432-0533 (Electronic) 0001-6322 (Linking).

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Pedros, C.; Gaud, G.; Bernard, I.; Kassem, S.; Chabod, M.; Lagrange, D.; Andreoletti, O.; Dejean, A. S.; Lesourne, R.; Fournie, G. J.; Saoudi, A.

An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development Journal Article

In: J Immunol, vol. 195, no. 4, pp. 1608-16, 2015, ISSN: 1550-6606 (Electronic) 0022-1767 (Linking).

Links | BibTeX

Martin-Blondel, G.; Bauer, J.; Uro-Coste, E.; Biotti, D.; Averseng-Peaureaux, D.; Fabre, N.; Dumas, H.; Bonneville, F.; Lassmann, H.; Marchou, B.; Liblau, R. S.; Brassat, D.

Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8(+) T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome Journal Article

In: Acta Neuropathol, vol. 129, no. 3, pp. 463-5, 2015, ISSN: 1432-0533 (Electronic) 0001-6322 (Linking).

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Hafler, D. A.; Astier, A. L.

Editorial: T cell regulation by the environment Journal Article

In: Front Immunol, vol. 6, pp. 229, 2015, ISSN: 1664-3224 (Print) 1664-3224 (Linking).

Links | BibTeX

2014

Outteryck, O.; Ongagna, J. C.; Brochet, B.; Rumbach, L.; Lebrun-Frenay, C.; Debouverie, M.; Zephir, H.; Ouallet, J. C.; Berger, E.; Cohen, M.; Pittion, S.; Laplaud, D.; Wiertlewski, S.; Cabre, P.; Pelletier, J.; Rico, A.; Defer, G.; Derache, N.; Camu, W.; Thouvenot, E.; Moreau, T.; Fromont, A.; Tourbah, A.; Labauge, P.; Castelnovo, G.; Clavelou, P.; Casez, O.; Hautecoeur, P.; Papeix, C.; Lubetzki, C.; Fontaine, B.; Couturier, N.; Bohossian, N.; Clanet, M.; Vermersch, P.; de Seze, J.; Brassat, D.; Network, Bionat; Cfsep,

A prospective observational post-marketing study of natalizumab-treated multiple sclerosis patients: clinical, radiological and biological features and adverse events. The BIONAT cohort Journal Article

In: Eur J Neurol, vol. 21, no. 1, pp. 40-8, 2014, ISSN: 1468-1331 (Electronic) 1351-5101 (Linking).

Links | BibTeX

2011

International Multiple Sclerosis Genetics, Consortium; Wellcome Trust Case Control, Consortium; Sawcer, S.; Hellenthal, G.; Pirinen, M.; Spencer, C. C.; Patsopoulos, N. A.; Moutsianas, L.; Dilthey, A.; Su, Z.; Freeman, C.; Hunt, S. E.; Edkins, S.; Gray, E.; Booth, D. R.; Potter, S. C.; Goris, A.; Band, G.; Oturai, A. B.; Strange, A.; Saarela, J.; Bellenguez, C.; Fontaine, B.; Gillman, M.; Hemmer, B.; Gwilliam, R.; Zipp, F.; Jayakumar, A.; Martin, R.; Leslie, S.; Hawkins, S.; Giannoulatou, E.; D'Alfonso, S.; Blackburn, H.; Martinelli Boneschi, F.; Liddle, J.; Harbo, H. F.; Perez, M. L.; Spurkland, A.; Waller, M. J.; Mycko, M. P.; Ricketts, M.; Comabella, M.; Hammond, N.; Kockum, I.; McCann, O. T.; Ban, M.; Whittaker, P.; Kemppinen, A.; Weston, P.; Hawkins, C.; Widaa, S.; Zajicek, J.; Dronov, S.; Robertson, N.; Bumpstead, S. J.; Barcellos, L. F.; Ravindrarajah, R.; Abraham, R.; Alfredsson, L.; Ardlie, K.; Aubin, C.; Baker, A.; Baker, K.; Baranzini, S. E.; Bergamaschi, L.; Bergamaschi, R.; Bernstein, A.; Berthele, A.; Boggild, M.; Bradfield, J. P.; Brassat, D.; Broadley, S. A.; Buck, D.; Butzkueven, H.; Capra, R.; Carroll, W. M.; Cavalla, P.; Celius, E. G.; Cepok, S.; Chiavacci, R.; Clerget-Darpoux, F.; Clysters, K.; Comi, G.; Cossburn, M.; Cournu-Rebeix, I.; Cox, M. B.; Cozen, W.; Cree, B. A.; Cross, A. H.; Cusi, D.; Daly, M. J.; Davis, E.; de Bakker, P. I.; Debouverie, M.; D'Hooghe M, B.; Dixon, K.; Dobosi, R.; Dubois, B.; Ellinghaus, D.; others,

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Journal Article

In: Nature, vol. 476, no. 7359, pp. 214-9, 2011, ISSN: 1476-4687 (Electronic) 0028-0836 (Linking).

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Dejean, A. S.; Hedrick, S. M.; Kerdiles, Y. M.

Highly specialized role of Forkhead box O transcription factors in the immune system Journal Article

In: Antioxid Redox Signal, vol. 14, no. 4, pp. 663-74, 2011, ISSN: 1557-7716 (Electronic) 1523-0864 (Linking).

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Couturier, N.; Bucciarelli, F.; Nurtdinov, R. N.; Debouverie, M.; Lebrun-Frenay, C.; Defer, G.; Moreau, T.; Confavreux, C.; Vukusic, S.; Cournu-Rebeix, I.; Goertsches, R. H.; Zettl, U. K.; Comabella, M.; Montalban, X.; Rieckmann, P.; Weber, F.; Muller-Myhsok, B.; Edan, G.; Fontaine, B.; Mars, L. T.; Saoudi, A.; Oksenberg, J. R.; Clanet, M.; Liblau, R. S.; Brassat, D.

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility Journal Article

In: Brain, vol. 134, no. Pt 3, pp. 693-703, 2011, ISSN: 1460-2156 (Electronic) 0006-8950 (Linking).

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Colacios, C.; Casemayou, A.; Dejean, A. S.; Gaits-Iacovoni, F.; Pedros, C.; Bernard, I.; Lagrange, D.; Deckert, M.; Lamouroux, L.; Jagodic, M.; Olsson, T.; Liblau, R. S.; Fournie, G. J.; Saoudi, A.

The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development Journal Article

In: J Exp Med, vol. 208, no. 11, pp. 2183-91, 2011, ISSN: 1540-9538 (Electronic) 0022-1007 (Linking).

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2009

Dejean, A. S.; Beisner, D. R.; Ch'en, I. L.; Kerdiles, Y. M.; Babour, A.; Arden, K. C.; Castrillon, D. H.; DePinho, R. A.; Hedrick, S. M.

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells Journal Article

In: Nat Immunol, vol. 10, no. 5, pp. 504-13, 2009, ISSN: 1529-2916 (Electronic) 1529-2908 (Linking).

Links | BibTeX

Societal impact

Our team aims at understanding the cellular and molecular determinants leading to inflammation and autoimmunity in the central nervous system. To this end, we have generated unique genetically modified mouse models on which innovative research can be conducted ranging from mechanistic studies to pre-clinical therapeutic testing. We have also developed unique biological resources from patients with MS or narcolepsy that allow us to translate directly to the clinic the relevance of our key findings (identification or validation of pathways contributing to disease susceptibility, identification of new biomarkers). Finally, we are involved in investigator-initiated therapeutic trials that open new possibilities for patients with CNS inflammatory or infectious diseases.

Our team is composed of a mix of senior and more junior investigators from seven countries and diverse backgrounds (physician, scientist, veterinary, pharmacist…). This favors a vivid and dynamic scientific environment and provides unique opportunities to develop both basic and translational research and even investigator-sponsored clinical trials. We benefit from a solid international visibility in the field of neuroimmunology. National and international collaborations of the highest scientific level have been built over the years. These networks give access to both scientific inputs and technological expertise for our projects. Some of our current lines of research have raised interest from Biotech or Pharma such as GSK, Biogen and Genzyme providing possible alternative sources of funding, while keeping our research independent.
Our team has been successful in obtaining a number of grants for the proposed projects from local, national or international origins.

Alumni

Post-docs :

  • Mars Lennart T
  • Piaggio Eliane
  • Zapula Jacques
  • Scheikl Tanja
  • Lazarczyk Macjek
  • Céline Colacios
  • Lamouroux Lucile
  • Ramadan Raouf
  • Xuan-Hung Nguyen
  • Manish Malviya
  • Lidia Yshii
  • Guillaume Gaud
  • Myriam Hayder
  • Familiades Julien
  • Coralie Fonte
  • Sally Al-Hajj
  • Elena Morandi

 

PhD

  • Céline Meyer
  • Pierre-Paul Axisa
  • Guillaume Martin-Blondel
  • Michael Michieletto
  • Mehdi Benamar
  • Raphaël Bernard-Valnet
  • Lucca Liliana
  • Stienne Caroline
  • Gebauer Christina
  • Kassem Sahar
  • Pedros Christophe
  • Saxena Amit
  • Couturier Nicolas
  • Bergereau Emilie
  • Bohossian Nora
  • Ordonez Laurence
  • Casemaiyou Audrey
  • Duguet Fanny
  • Chabod Mariane
  • Cabarocas Julie
  • Cassan Cécile
  • Emeline Joulia
  • Arantxa Agesta
  • Leila Khajavi
  • Remi Marrocco
  • Arnaud Delbello
Collaborations
Becher Burkhard , Institute of Experimental Immunology, University of Zurich, Switzerland
Casanova Jean-Laurent , the Rockfeller University , NY, USA
Dauvilliers Yves, Department of Sleep Disorders, Montpellier, France
Engelhardt Britta, Theodor Kocher Institute, University of Bern, Switzerland
Hedrick Stephen M , UCSD, La jolla, CA, USA)
Lassmann Hans & Jan Bauer, Brain Research Institute, Vienne, Austria
Malissen Bernard, CIML, Marseille, France
Olsson Tomas, Karolinska Hospital, Stockholm, Sweden
Peyron Christelle, INSERM U1028, CNRS UMR 5292, Center for Research in Neuroscience, Lyon, France
Sarry Jean-Emmanuel , centre de recherche en cancérologie de Toulouse, FranceManuel Comabella VHIR, Barcelone, Spain
Schiltz Odile & Anne Gonzalez-de-Peredo, IPBS, Toulouse, France
Fernandes Adelaide, Lisbon, Portugal
Simon Michel, UDEAR, Toulouse, France
Tafti Mehdi, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Thouvenot Eric, Institute of functional genomic, Montpellier, France
Walzer Thierry, Centre International de Recherche en Infectiologie, Lyon, France
Wiendl Heinz, Department of Neurology, University of Münster, Germany
Zytnicki Matthias, Unité de Mathématiques et Informatique Appliquées de Toulouse, France

Collaborations within the Center:

Daniel Dunia
Jacques Izopet
Jean-Charles Guery
Manuel Diaz-Munoz
Michel Simon
Nabila Jabrane
Nicolas Blanchard
Nicolas Fazilleau
Rémi Poupot
Renaut Lesourne
Sylvie Gerder
Loic Dupré
Joost van Meerwijk

Partenaires Equipe 5

ARSEP

ARSEP

Agence nationale de la recherche

Agence nationale de la recherche

Région Occitanie

Région Occitanie

AFM

AFM

GSK

GSK

Fondation Bettencourt Schueller

Fondation Bettencourt Schueller

Fondation maladies rares

Fondation maladies rares

CNRS

CNRS

ATIP AVENIR

ATIP AVENIR

Fondation ARC

Fondation ARC