TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women

Pascal Azar (*), José Enrique Mejía (*), Claire Cenac (*), Arnoo Shaiykova, Ali Youness, Sophie Laffont, Asma Essat, Jacques Izopet, Caroline Passaes, Michaela Müller-Trutwin, Pierre Delobel, Laurence Meyer, et Jean-Charles Guéry

(*) Co-premiers auteurs.
JCI Insight,

For the first time, a research team has identified a sex-dependent genetic mechanism in the innate immune response that takes place during the acute phase of HIV-1 infection. This work, published in JCI Insight on June 18 and supported by the ANRS and SIDACTION, sheds new light on the  role of  the TLR7-diven production of type-1 IFN by plasmacytoid dendritic cells during the first stage of HIV-1 infection and its consequences on the viral load in women. This publication contributes to a better understanding of the mechanisms of HIV-1 infection, which remains a global health problem with 1.7 million people newly infected in 2018 worldwide1. This work was carried out by the team of Jean-Charles Guéry from the Center for Physiopathology of Toulouse Purpan (CPTP), in collaboration with Laurence Meyer from the Center for Research in Epidemiology and Population Health, Pierre Delobel from the Department of Infectious and Tropical Diseases from the Toulouse University Hospital and Michaela Müller-Trutwin from the HIV, Inflammation and Persistence Unit at the Institut Pasteur.

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