@article{Paul2011,

title = {Prevalence and risk factors for xerosis in the elderly: a cross-sectional epidemiological study in primary care.},

author = {Paul, C and Maumus-Robert, S and Mazereeuw-Hautier, J and Guyen, C N and Saudez, X and Schmitt, A M},

doi = {10.1159/000334631},

issn = {1421-9832 (Electronic)},

year  = {2011},

date = {2011-01-01},

journal = {Dermatology (Basel, Switzerland)},

volume = {223},

number = {3},

pages = {260--265},

abstract = {BACKGROUND: Limited information is available concerning the prevalence and risk factors of xerosis in the elderly. OBJECTIVE: To establish the prevalence of xerosis and associated factors in elderly patients. METHODS: A national, multicenter, observational, cross-sectional study in patients aged 65 or older was performed. The data collected by general practitioners were demographics and medical history, including history of atopic disease. Xerosis was evaluated using the Overall Dry Skin score. RESULTS: 756 patients were included. The prevalence of xerosis was 55.6%. Xerosis was significantly associated with older age (OR: 1.48, 95% CI: 1.16-1.89), female sex (OR: 1.80, 95 CI%: 1.29-2.53), treatments that can potentially cause xerosis (OR: 2.21, 95 CI%: 1.54-3.17), itching during sweating (OR: 7.11, 95% CI: 3.90-12.95), a history of dry skin (OR: 2.89, 95% CI: 1.65-5.08) and a history of atopic dermatitis (OR: 3.60, 95% CI: 1.99-6.52). CONCLUSION: Xerosis is highly prevalent in the elderly. A history of atopy, especially atopic dermatitis, is associated with an increased risk of xerosis in the elderly.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{millot_erythropoietin_2010,

title = {Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation},

author = {Millot, Sarah and Andrieu, Valérie and Letteron, Philippe and Lyoumi, Saïd and Hurtado-Nedelec, Margarita and Karim, Zoubida and Thibaudeau, Olivier and Bennada, Samira and Charrier, Jean-Luc and Lasocki, Sigismond and Beaumont, Carole},

doi = {10.1182/blood-2010-04-281840},

issn = {1528-0020},

year  = {2010},

date = {2010-12-01},

journal = {Blood},

volume = {116},

number = {26},

pages = {6072--6081},

abstract = {Mouse bone marrow erythropoiesis is homeostatic, whereas after acute anemia, bone morphogenetic protein 4 (BMP4)-dependent stress erythropoiesis develops in the spleen. The aim of this work was to compare spleen stress erythropoiesis and bone marrow erythropoiesis in a mouse model of zymosan-induced generalized inflammation, which induces long-lasting anemia and to evaluate the ability of erythropoietin (Epo) injections to correct anemia in this setting. The effects of zymosan and/or Epo injections on erythroid precursor maturation and apoptosis, serum interferon-γ levels, hematologic parameters, and spleen BMP4 expression were analyzed, as well as the effect of zymosan on red blood cell half-life. We found that bone marrow erythropoiesis is suppressed by inflammation and does not respond to Epo administration, despite repression of erythroblast apoptosis. On the contrary, a robust erythropoietic response takes place in the spleen after Epo injections in both control and zymosan-induced generalized inflammation mice. This specific response implies Epo-mediated induction of BMP4 expression by F4/80(+) spleen macrophages, proliferation of stress burst-forming units-erythroid, and increased number of spleen erythroblasts. It allows only partial recovery of anemia, probably because of peripheral destruction of mature red cells. It is not clear whether similar BMP4-dependent stress erythropoiesis can occur in human bone marrow after Epo injections.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Schmid2010,

title = {Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread},

author = {Sonja Schmid and Philippe Metz and Christine M. A. Prat and Daniel Gonzalez-Dunia and Martin Schwemmle},

doi = {10.1007/s00705-010-0645-9},

issn = {1432-8798},

year  = {2010},

date = {2010-05-00},

urldate = {2010-05-00},

journal = {Arch Virol},

volume = {155},

number = {5},

pages = {789--793},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN14b,

title = {Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments},

author = {Davignon, J. L. and Boyer, J. F. and Jamard, B. and Nigon, D. and Constantin, A. and Cantagrel, A.},

url = {https://www.ncbi.nlm.nih.gov/pubmed/20633267},

doi = {10.1186/ar3083},

issn = {1478-6362 (Electronic) 

1478-6354 (Linking)},

year  = {2010},

date = {2010-01-01},

journal = {Arthritis Res Ther},

volume = {12},

number = {4},

pages = {R142},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN156,

title = {Thymic selection and lineage commitment of CD4+Foxp3+ regulatory T lymphocytes},

author = {Romagnoli, P. and van Meerwijk, J. P. M.},

year  = {2010},

date = {2010-01-01},

journal = {Prog Mol Biol Transl Sci.},

volume = {92},

pages = {251-77},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{szutkowska_zeta-crystallin_2009,

title = {Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability},

author = {Szutkowska, Marta and Vernimmen, Catherine and Debaix, Huguette and Devuyst, Olivier and Friedlander, Gérard and Karim, Zoubida},

doi = {10.1038/ki.2009.265},

issn = {1523-1755},

year  = {2009},

date = {2009-10-01},

journal = {Kidney International},

volume = {76},

number = {7},

pages = {730--738},

abstract = {The Na+/K+/2Cl- cotransporter (BSC1/NKCC2) is the major transporter mediating sodium chloride and ammonium absorption in the medullary thick ascending limb. A loss-of-function mutation of BSC1 is responsible for Bartter's syndrome. We previously showed both in vivo and in vitro that acidosis increases the expression and activity of BSC1 and that acid pH enhances the stability of BSC1 mRNA by mechanisms involving its 3'-untranslated region (UTR). zeta-Crystallin is a pH response factor that protects the mitochondrial glutaminase mRNA by a specific interaction with AU-rich motifs. Here we identified the molecular determinant(s) within the 3'-UTR that are responsible for BSC1-mRNA expression and assessed the involvement of zeta-crystallin in this regulation. Deleting three out of six conserved AU-rich motifs drastically reduced the expression of BSC1-mRNA with maximal effect for motif 3 at position 870 of the 3'UTR. This motif was responsible for pH and zeta-crystallin-induced stability of BSC1 mRNA. The abundance of zeta-crystallin was increased by acid pH and its overexpression increased the stability of BSC1 mRNA, but its RNA silencing inhibited acid pH-induced BSC1 expression. Therefore the 3'UTR of BSC1-mRNA is a target for zeta-crystallin. The induction of zeta-crystallin by an acid pH plays an important role in preventing BSC1 mRNA decay, thus increasing its expression and activity.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Prat2009,

title = {Mutation of the Protein Kinase C Site in Borna Disease Virus Phosphoprotein Abrogates Viral Interference with Neuronal Signaling and Restores Normal Synaptic Activity},

author = {Christine M. A. Prat and Sonja Schmid and Fanny Farrugia and Nicolas Cenac and Gwendal Le Masson and Martin Schwemmle and Daniel Gonzalez-Dunia},

editor = {Raul Andino},

doi = {10.1371/journal.ppat.1000425},

issn = {1553-7374},

year  = {2009},

date = {2009-05-08},

urldate = {2009-05-08},

journal = {PLoS Pathog},

volume = {5},

number = {5},

publisher = {Public Library of Science (PLoS)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN19,

title = {Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells},

author = {Dejean, A. S. and Beisner, D. R. and Ch'en, I. L. and Kerdiles, Y. M. and Babour, A. and Arden, K. C. and Castrillon, D. H. and DePinho, R. A. and Hedrick, S. M.},

url = {http://www.ncbi.nlm.nih.gov/pubmed/19363483},

doi = {10.1038/ni.1729},

issn = {1529-2916 (Electronic) 

1529-2908 (Linking)},

year  = {2009},

date = {2009-01-01},

journal = {Nat Immunol},

volume = {10},

number = {5},

pages = {504-13},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{karim_nherf1_2008,

title = {NHERF1 mutations and responsiveness of renal parathyroid hormone},

author = {Karim, Zoubida and Gérard, Bénédicte and Bakouh, Naziha and Alili, Rohia and Leroy, Christine and Beck, Laurent and Silve, Caroline and Planelles, Gabrielle and Urena-Torres, Pablo and Grandchamp, Bernard and Friedlander, Gérard and Prié, Dominique},

doi = {10.1056/NEJMoa0802836},

issn = {1533-4406},

year  = {2008},

date = {2008-09-01},

journal = {The New England Journal of Medicine},

volume = {359},

number = {11},

pages = {1128--1135},

abstract = {Impaired renal phosphate reabsorption, as measured by dividing the tubular maximal reabsorption of phosphate by the glomerular filtration rate (TmP/GFR), increases the risks of nephrolithiasis and bone demineralization. Data from animal models suggest that sodium-hydrogen exchanger regulatory factor 1 (NHERF1) controls renal phosphate transport. We sequenced the NHERF1 gene in 158 patients, 94 of whom had either nephrolithiasis or bone demineralization. We identified three distinct mutations in seven patients with a low TmP/GFR value. No patients with normal TmP/GFR values had mutations. The mutants expressed in cultured renal cells increased the generation of cyclic AMP (cAMP) by parathyroid hormone (PTH) and inhibited phosphate transport. These NHERF1 mutations suggest a previously unrecognized cause of renal phosphate loss in humans.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum},

author = {Blanchard, N. and Gonzalez, F. and Schaeffer, M. and Joncker, N. T. and Cheng, T. and Shastri, A. J. and Robey, E. A. and Shastri, N.},

year  = {2008},

date = {2008-01-01},

journal = {Nat Immunol},

volume = {9},

number = {8},

pages = {937-44},

abstract = {The parasite Toxoplasma gondii replicates in a specialized intracellular vacuole and causes disease in many species. Protection from toxoplasmosis is mediated by CD8(+) T cells, but the T. gondii antigens and host genes required for eliciting protective immunity are poorly defined. Here we identified GRA6, a polymorphic protein secreted in the parasitophorous vacuole, as the source of the immunodominant and protective decapeptide HF10 presented by the H-2L(d) major histocompatibility complex class I molecule. Presentation of the HF10-H-2L(d) ligand required proteolysis by ERAAP, the endoplasmic reticulum aminopeptidase associated with antigen processing. Consequently, expansion of protective CD8(+) T cell populations was impaired in T. gondii-infected ERAAP-deficient mice, which were more susceptible to toxoplasmosis. Thus, endoplasmic reticulum proteolysis is critical for eliciting protective immunity to a vacuolar parasite.},

note = {NLM 

In-Process 

Journal Article 

Research Support, N.I.H., Extramural 

Research Support, Non-U.S. Gov't DEP - 20080629},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN137,

title = {Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes},

author = {Joffre, O. and Santolaria, T. and Calise, D. and Al Saati, T. and Hudrisier, D. and Romagnoli, P. and van Meerwijk, J. P. M.},

year  = {2008},

date = {2008-01-01},

journal = {Nature Medicine},

volume = {14},

number = {1},

pages = {88-92},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN153,

title = {[Tregs-based immunotherapy: an efficient way to fully inhibit acute and chronic rejection.]},

author = {Joffre, O. and Santolaria, T. and van Meerwijk, J.P.M.},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18789210},

doi = {00/00/0C/B6/ [pii]},

issn = {0767-0974 (Print)},

year  = {2008},

date = {2008-01-01},

journal = {Med Sci (Paris)},

volume = {24},

number = {8-9},

pages = {689-691},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN155,

title = {Murine CD8(+) regulatory T lymphocytes: The new era},

author = {Pomie, C. and Menager-Marcq, I. and van Meerwijk, J.P.M.},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18817827},

doi = {S0198-8859(08)00450-3 [pii] 

10.1016/j.humimm.2008.08.288},

issn = {0198-8859 (Print)},

year  = {2008},

date = {2008-01-01},

journal = {Hum Immunol},

volume = {69},

pages = {708-714},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{b,

title = {Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum},

author = {Blanchard, N. and Gonzalez, F. and Schaeffer, M. and Joncker, N. T. and Cheng, T. and Shastri, A. J. and Robey, E. A. and Shastri, N.},

year  = {2008},

date = {2008-01-01},

journal = {Nat Immunol},

volume = {9},

number = {8},

pages = {937-44},

abstract = {The parasite Toxoplasma gondii replicates in a specialized intracellular vacuole and causes disease in many species. Protection from toxoplasmosis is mediated by CD8(+) T cells, but the T. gondii antigens and host genes required for eliciting protective immunity are poorly defined. Here we identified GRA6, a polymorphic protein secreted in the parasitophorous vacuole, as the source of the immunodominant and protective decapeptide HF10 presented by the H-2L(d) major histocompatibility complex class I molecule. Presentation of the HF10-H-2L(d) ligand required proteolysis by ERAAP, the endoplasmic reticulum aminopeptidase associated with antigen processing. Consequently, expansion of protective CD8(+) T cell populations was impaired in T. gondii-infected ERAAP-deficient mice, which were more susceptible to toxoplasmosis. Thus, endoplasmic reticulum proteolysis is critical for eliciting protective immunity to a vacuolar parasite.},

note = {NLM 

In-Process 

Journal Article 

Research Support, N.I.H., Extramural 

Research Support, Non-U.S. Gov't DEP - 20080629},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN135,

title = {Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection},

author = {Ribot, J. and Enault, G. and Pilipenko, S. and Huchencq, A. and Calise, M. and Hudrisier, D. and Romagnoli, P. and van Meerwijk, J. P. M.},

year  = {2007},

date = {2007-01-01},

journal = {J. Immunol.},

volume = {179},

pages = {6741-6748},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN127,

title = {CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation},

author = {Joffre, O. and van Meerwijk, J. P. M.},

year  = {2006},

date = {2006-01-01},

journal = {Seminars in Immunology},

volume = {18},

number = {2},

pages = {128-135},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN132,

title = {CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice},

author = {Menager-Marcq, I. and Pomie, C. and Romagnoli, P. and van Meerwijk, J. P. M.},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17087950},

year  = {2006},

date = {2006-01-01},

journal = {Gastroenterology},

volume = {131},

number = {6},

pages = {1775-85},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN128,

title = {Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR-repertoire},

author = {Ribot, J. and Romagnoli, P. and van Meerwijk, J. P. M.},

year  = {2006},

date = {2006-01-01},

journal = {J. Immunol.},

volume = {177},

number = {2},

pages = {1101-1107},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{RN133,

title = {An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes},

author = {Tellier, J. and van Meerwijk, J. P. M. and Romagnoli, P.},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16943258},

year  = {2006},

date = {2006-01-01},

journal = {Int Immunol},

volume = {18},

number = {11},

pages = {1509-1519},

keywords = {},

pubstate = {published},

tppubtype = {article}

}